Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200364
Abstract: There is an emerging interest in utilizing synthetic multivalent inhibitors that comprise of multiple inhibitor moieties linked on a common scaffold to achieve strong and selective enzyme inhibition. As multivalent inhibition is impacted by valency… read more here.
Keywords: inhibition; valency linker; linker; linker length ... See more keywords
Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00265
Abstract: The estrone ligand is used for modifying nanoparticle surfaces to improve their targeting effect on cancer cell lines. However, to date, there is no common agreement on the ideal linker length to be used for… read more here.
Keywords: polymer; linker; linker length; polymer coated ... See more keywords
Improving the Catalytic Performance of a Talaromyces leycettanus α-Amylase by Changing the Linker Length.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b00838
Abstract: A novel α-amylase, Amy13A, that consists of these domains was identified in Talaromyces leycettanus JCM12802: catalytic TIM-barrel fold, domain B, domain C, Thr/Ser-rich linker region, and C-terminal CBM20 domain. The wild type and three mutant… read more here.
Keywords: amylase; linker; linker length; talaromyces leycettanus ... See more keywords
The effect of linker length on ConA and DC-SIGN binding of S-glucosyl functionalized poly(2-oxazoline)s
Sign Up to like & getrecommendations! Published in 2018 at "Polymer Chemistry"
DOI: 10.1039/c7py01939d
Abstract: A new monomer, 2-[2-(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosylthio) propyl)]-2-oxazoline (Ac4Glc-S-Ox), was synthesized by direct addition of 2,3,4,6-Tetra-O-acetyl-1-thio-β-D-glucopyranose (Ac4Glc-SH) to 2-Isopropenyl-2-oxazoline (iPOx) in the presence of solid butyl amine resin via thiol-ene click reaction. The living cationic ring-opening polymerization was… read more here.
Keywords: effect linker; linker; linker length; oxazoline ... See more keywords
Investigations into the effects of linker length elongation on the behaviour of calcium-responsive MRI probes.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt02672j
Abstract: Understanding the relationship between chemical structure and the effectiveness of bioresponsive magnetic resonance imaging (MRI) contrast agents can offer help to identify key components required for the future development of such probes. Here, we report… read more here.
Keywords: calcium responsive; linker length; behaviour; calcium ... See more keywords
Linker length affects photostability of protein-targeted sensor of cellular microviscosity.
Sign Up to like & getrecommendations! Published in 2019 at "Methods and applications in fluorescence"
DOI: 10.1088/2050-6120/ab481f
Abstract: Viscosity sensitive fluorophores termed 'molecular rotors' represent a convenient and quantitative tool for measuring intracellular viscosity via Fluorescence Lifetime Imaging Microscopy (FLIM). We compare the FLIM performance of two BODIPY-based molecular rotors bound to HaloTag… read more here.
Keywords: protein; length affects; affects photostability; linker length ... See more keywords
Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030404
Abstract: LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although several… read more here.
Keywords: lc8; hub protein; linker length; heterogeneity multivalent ... See more keywords