Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-019-00527-5
Abstract: Protease activated receptors (PARs) transactivate both epidermal growth factor receptors (EGFR) and transforming growth factor (TGF)-β receptors (TGFBR1) in vascular smooth muscle leading to the increased expression of genes (CHST11 and CHSY1) which are rate… read more here.
Keywords: phosphorylation; transactivation; linker region; smad linker ... See more keywords
The acidic domain of Hmga2 and the domain’s linker region are critical for driving self-renewal of hematopoietic stem cell
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-021-03274-9
Abstract: High mobility group AT-hook 2 (Hmga2) is a chromatin modifier protein that plays a critical role in fetal development and leukemia propagation by binding to chromatin and DNA via its AT-hook domains. However, the molecular… read more here.
Keywords: self renewal; domain; linker region; acidic domain ... See more keywords
The linker region of LINEs modulates DNA cleavage and DNA polymerization.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113809
Abstract: Long interspersed elements (LINEs) replicate by target primed reverse transcription (TPRT). Insertion involves two half reactions. Each half reaction involves DNA cleavage followed by DNA synthesis. The linker region, located just beyond the reverse transcriptase… read more here.
Keywords: dna cleavage; linker region; linker; dna ... See more keywords
G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.03.004
Abstract: &NA; Smads (sma/mothers against decapentaplegic) are transcription factors, which can be phosphorylated in the carboxy terminal (pSmad2/3C) or in the structurally central linker region (pSmad2/3 L). Only receptor kinases such as Transforming Growth Factor (TGF)‐&bgr;… read more here.
Keywords: carboxy terminal; region phosphorylation; phosphorylation; linker region ... See more keywords
The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02697-21
Abstract: The polysaccharide-disintegrating carbohydrate-active enzymes (CAZymes) are often found with multimodular architecture, where the catalytic domain is connected to an accessory CBM domain with the help of a flexible linker region. So far, the linker has… read more here.
Keywords: role; cbm; linker region; linker ... See more keywords
Effect of CBM1 and linker region on enzymatic properties of a novel thermostable dimeric GH10 xylanase (Xyn10A) from filamentous fungus Aspergillus fumigatus Z5
Sign Up to like & getrecommendations! Published in 2018 at "AMB Express"
DOI: 10.1186/s13568-018-0576-5
Abstract: Xylanase with a high thermostability will satisfy the needs of raising the temperature of hydrolysis to improve the rheology of the broth in industry of biomass conversion. In this study, a xylanase gene (xyn10A), predicted… read more here.
Keywords: cbm1; xylanase; xyn10a; linker region ... See more keywords
Thrombin improves diabetic wound healing by ERK dependent and independent Smad2/3 linker region phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220511125237
Abstract: BACKGROUND Impaired wound healing is one of the most noteworthy features and troublesome complications of diabetes mellitus, which arouse a rising global health concern but without potent remedies. Thrombin is the major hemostatic agent applied… read more here.
Keywords: smad2; phosphorylation; wound healing; linker region ... See more keywords
Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine–glycine-rich protein
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1134509
Abstract: One of the key proteins that are present in the Z-disc of cardiac tissues, CSRP3, has been implicated in dilated and hypertrophic cardiomyopathy leading to heart failure. Although multiple cardiomyopathy-related mutations have been reported to… read more here.
Keywords: disordered linker; linker region; flexibility disordered; lim domains ... See more keywords
Role for Gag-CA Interdomain Linker in Primate Lentiviral Replication
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.01831
Abstract: Gag proteins underlie retroviral replication by fulfilling numerous functional roles at various stages during viral life cycle. Out of the four mature proteins, Gag-capsid (CA) is a major component of viral particles, and has been… read more here.
Keywords: gag; linker region; linker; replication ... See more keywords
Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158124
Abstract: Osteoarthritis (OA) is a degenerative joint disease characterized by irreversible cartilage damage, inflammation and altered chondrocyte phenotype. Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial for blocking hypertrophy. The post-translational modifications of these SMAD… read more here.
Keywords: smad2 linker; inflammation; linker region; linker ... See more keywords
Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051195
Abstract: Canocapavir is a novel antiviral agent with characteristics of core protein allosteric modulators (CpAMs) that is currently in a phase II clinical trial for treatment of hepatitis B virus (HBV) infection. Herein, we show that… read more here.
Keywords: core protein; hbv; linker region; canocapavir ... See more keywords