Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.
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DOI: 10.1021/acs.molpharmaceut.7b00657
Abstract: Diacylglycerol lipase-beta (DAGLĪ²) hydrolyzes arachidonic acid (AA)-containing diacylglycerols to produce bioactive lipids including endocannabinoids and AA-derived eicosanoids involved in regulation of inflammatory signaling. Previously, we demonstrated that DAGLĪ² inactivation using the triazole urea inhibitor KT109… read more here.
Keywords: diacylglycerol lipase; inhibitors macrophages; delivery; lipase beta ... See more keywords