Identification and development of an irreversible monoacylglycerol lipase (MAGL) positron emission tomography (PET) radioligand with high specificity.
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DOI: 10.1021/acs.jmedchem.9b00847
Abstract: Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Pre-clinically, inhibition of MAGL is known to provide therapeutic benefits for a number… read more here.
Keywords: pet; monoacylglycerol lipase; emission tomography; lipase magl ... See more keywords