Downregulation of adipose triglyceride lipase by EB viral‐encoded LMP2A links lipid accumulation to increased migration in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12824
Abstract: Epstein–Barr virus (EBV)‐associated nasopharyngeal carcinoma (NPC) is one of the most common human cancers in South‐East Asia exhibiting typical features of lipid accumulation. EBV‐encoded latent membrane protein 2A (LMP2A) is expressed in most NPCs enhancing… read more here.
Keywords: accumulation; lipid accumulation; migration; downregulation ... See more keywords
Effect of atorvastatin on lipoxygenase pathway‐related gene expression in an in vitro model of lipid accumulation in hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13552
Abstract: Lipid accumulation in hepatocytes can result from an imbalance between lipid acquisition and lipid catabolism. In recent years, it has been discovered that eicosanoids derived from arachidonic acid (AA) have the potential to create specialized… read more here.
Keywords: vitro model; lipoxygenase pathway; lipid accumulation; expression ... See more keywords
Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202408906
Abstract: Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self‐molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential.… read more here.
Keywords: guanidine; lipid accumulation; accumulation; ampk pathway ... See more keywords
Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417489
Abstract: Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and is driven primarily by macrophage‐mediated lipid accumulation and inflammatory processes. Conventional cardiovascular pharmacotherapies address these pathological mechanisms but… read more here.
Keywords: decursin loaded; lipid accumulation; atherosclerosis; target ... See more keywords
Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury
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DOI: 10.1002/advs.202506313
Abstract: Spinal cord injury (SCI) substantially affects functional capacity and the immune system plays a crucial role in recovery. Examining alterations in microglia metabolism can lead to improved repair mechanisms; however, the molecular subtyping of microglia… read more here.
Keywords: cord; lipid accumulation; spinal cord; cord injury ... See more keywords
Mechanism of the oxidative stress‐mediated increase in lipid accumulation by the bacterium, R. opacus PD630: Experimental analysis and genome‐scale metabolic modeling
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27330
Abstract: Appropriate species of oleaginous bacteria, with their high growth rates and lipid accumulation capabilities, can be good contenders for industrial triacylglycerol (TAG) production, compared to microalgae. Further, oxidative stress (OS) can be used to significantly… read more here.
Keywords: accumulation; mechanism; lipid accumulation; increase ... See more keywords
miR‐497 accelerates oxidized low‐density lipoprotein‐induced lipid accumulation in macrophages by repressing the expression of apelin
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10808
Abstract: microRNAs (miRNAs) play important roles in the pathogenesis of atherosclerosis. A previous study has reported that miR‐497 is elevated in advanced atherosclerotic lesions in an apoE‐deficient (apoE‐/‐) mouse model. The purpose of this study is… read more here.
Keywords: lipid accumulation; apelin; mir; mir 497 ... See more keywords
Advanced Imaging and Cytometric Techniques to Characterize Lipid Accumulation in Wolman Disease
Sign Up to like & getrecommendations! Published in 2025 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24949
Abstract: Wolman disease (WD) is a severe lysosomal storage disorder characterized by fatal lipid accumulation caused by the deficiency of a lipid metabolic enzyme, Lysosomal Acid Lipase (LAL), involved in the lysosomal hydrolysis of cholesterols and… read more here.
Keywords: lal deficient; wolman disease; lipid accumulation;
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22027
Abstract: This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro. In vivo, mice were administrated with 6 mg… read more here.
Keywords: dhea induced; pcos mice; lipid accumulation; mice ... See more keywords
Regulation of lipid accumulation in Schizochytrium sp. ATCC 20888 in response to different nitrogen sources
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Lipid Science and Technology"
DOI: 10.1002/ejlt.201700025
Abstract: Summary Regulation of lipid accumulation in Schizochytrium sp. ATCC 20888 in response to different nitrogen sources was investigated in this study. Nitrogen sources had important effects on the cell growth, lipid accumulation and docosahexaenoic acid… read more here.
Keywords: nitrogen; nitrogen sources; accumulation schizochytrium; lipid accumulation ... See more keywords
Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22994
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease with the formation and accumulation of macrophage-derived foam cells in the subendothelial space of blood vessels as one major characteristic. Insulin-like growth factor 2 messenger RNA (mRNA) binding… read more here.
Keywords: expression; accumulation; silencing igf2bp1; lipid accumulation ... See more keywords