Determination of lipid bilayer affinities and solvation characteristics by electrokinetic chromatography using polymer‐bound lipid bilayer nanodiscs
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700308
Abstract: Styrene‐maleic acid polymer‐bound lipid bilayer nanodiscs have been investigated and characterized by electrokinetic chromatography. Linear solvation energy relationship analysis was employed to characterize the changes in solvation environment of nanodiscs of varied belt to lipid… read more here.
Keywords: electrokinetic chromatography; chemistry; lipid bilayer; composition ... See more keywords
Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes
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DOI: 10.1002/open.201900374
Abstract: Abstract We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous… read more here.
Keywords: lipid bilayer; bilayer membranes; aromatic fluorination; fluorination multiblock ... See more keywords
Importance of the RpoE Regulon in Maintaining the Lipid Bilayer during Antimicrobial Treatment with the Polycationic Agent, Chlorhexidine
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201700285
Abstract: The emergence of multidrug resistance in bacteria has reached alarming levels. To solve this growing problem, discovery of novel cellular targets or pathways important for antimicrobial resistance is urgently needed. In this study, we explored… read more here.
Keywords: rpoe regulon; agent chlorhexidine; rpoe; chx ... See more keywords
Molecular Dynamics Simulation and Analysis of the Antimicrobial Peptide-Lipid Bilayer Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6737-7_8
Abstract: A great deal of research has been undertaken in order to discover antimicrobial peptides (AMPs) with unexploited mechanisms of action to counteract the health-threatening issues associated with bacterial resistance. The intrinsic effectiveness of AMPs is… read more here.
Keywords: lipid bilayer; dynamics simulation; peptide lipid; molecular dynamics ... See more keywords
Reconstitution and Characterization of BCL-2 Family Proteins in Lipid Bilayer Nanodiscs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8861-7_16
Abstract: The BCL-2 family proteins are key regulators of programmed cell death or apoptosis, and represent important targets for the development of anticancer drugs. Because their functions are intimately connected with intracellular membranes, it is important… read more here.
Keywords: bilayer nanodiscs; bcl family; family; lipid bilayer ... See more keywords
Effect of drug amlodipine on the charged lipid bilayer cell membranes DMPS and DMPS + DMPC: a molecular dynamics simulation study
Sign Up to like & getrecommendations! Published in 2018 at "European Biophysics Journal"
DOI: 10.1007/s00249-018-1317-z
Abstract: In this work, the effects of the anti-hypertensive drug amlodipine in native and PEGylated forms on the malfunctioning of negatively charged lipid bilayer cell membranes constructed from DMPS or DMPS + DMPC were studied by molecular dynamics… read more here.
Keywords: drug; lipid bilayer; cell; drug amlodipine ... See more keywords
Lipid bilayer stress in obesity‐linked inflammatory and metabolic disorders
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.022
Abstract: &NA; The maintenance of the characteristic lipid compositions and physicochemical properties of biological membranes is essential for their proper function. Mechanisms allowing to sense and restore membrane homeostasis have been identified in prokaryotes for a… read more here.
Keywords: lipid bilayer; bilayer stress; membrane; obesity ... See more keywords
Effect of the cholesterol on electroporation of planar lipid bilayer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2021.108004
Abstract: Electroporation threshold depends on the membrane composition, with cholesterol being one of its key components already studied in the past, but the results were inconclusive. The aim of our study was to determine behaviour of… read more here.
Keywords: cholesterol; planar lipid; electroporation; lipid bilayer ... See more keywords
Regulation of KcsA by Bilayer-Modifying Molecules
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DOI: 10.1016/j.bpj.2016.11.1243
Abstract: The coupling between membrane proteins and their surrounding lipid bilayer make understanding the membrane lipid regulation of membrane proteins key to understanding their function. The membrane lipid regulation of membrane protein function ranges from specific… read more here.
Keywords: bilayer modifying; lipid bilayer; bilayer properties; bilayer ... See more keywords
Structural Characterization of CwsA in a Lipid Bilayer with ssNMR
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2642
Abstract: Tuberculosis (TB) is a leading infectious disease killer worldwide caused by Mycobacterium tuberculosis (Mtb). According to World Health Organization (WHO), 9.6 million people became ill with TB and 1.5 million died from the disease in… read more here.
Keywords: cwsa lipid; lipid bilayer; cwsa; structural characterization ... See more keywords
Investigating the Effects of the Membrane Dipole Field on the Structure and Function of a Model Membrane Protein
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.272
Abstract: Lipid bilayer membranes are composed of hundreds of lipids, sterols and proteins, which organize in to a heterogeneous, structural scaffold that controls critical elements of biological function. The interactions of all of these molecules are… read more here.
Keywords: membrane dipole; field; lipid bilayer; dipole field ... See more keywords