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   Articles with "lipid binding" as a keyword



A Predicted Structure of the Angiomotin Lipid Binding Domain

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.336

Abstract: Amots are a family of adapter proteins that modulate cellular polarity, differentiation, proliferation, and migration. Amot family members also have a characteristic lipid-binding domain, the coiled coil homology (ACCH) Domain that selectively targets the protein… read more here.

Keywords: lipid binding; predicted structure; binding domain; domain ... See more keywords

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

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recommendations! Published in 2019 at "Immunity"

DOI: 10.1016/j.immuni.2019.04.017

Abstract: Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases triggers the oligomerization and lipid binding by its N-terminal domain, which assembles membrane… read more here.

Keywords: murine; lipid binding; binding oligomerization; crystal structures ... See more keywords
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LiaRS reporter assay: A simple tool to identify lipid II binding moieties in lantibiotic nukacin ISK-1.

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recommendations! Published in 2017 at "Journal of bioscience and bioengineering"

DOI: 10.1016/j.jbiosc.2016.10.002

Abstract: Binding to lipid II is an important step in the mode of action of most lantibiotics targeting the bacterial cell wall. We applied the Bacillus subtilis two-component system, LiaRS, that is known to respond to… read more here.

Keywords: identify lipid; lipid binding; nukacin isk; binding moieties ... See more keywords

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.11.033

Abstract: The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally associated… read more here.

Keywords: coq9; biosynthesis; lipid binding; coenzyme ... See more keywords

Alanine Scanning to Define Membrane Protein-Lipid Interaction Sites Using Native Mass Spectrometry.

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00717

Abstract: Lipids surrounding membrane proteins interact with different sites on the protein with varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the structure, function, and stability of membrane proteins. Thus, to… read more here.

Keywords: native mass; binding sites; lipid binding; membrane ... See more keywords

Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.

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recommendations! Published in 2019 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.8b00579

Abstract: Six α-synuclein (aSyn) point mutations are currently known to be associated with familial parkinsonism: A30P, E46K, H50Q, G51D, A53E, and A53T. We performed a comprehensive in vitro analysis to study the impact of all aSyn… read more here.

Keywords: fluorescence; lipid binding; different effects; binding aggregation ... See more keywords

Lipid binding attenuates channel closure of the outer membrane protein OmpF

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1721152115

Abstract: Significance Outer-membrane porins are often considered as passive conduits of small molecules across lipid bilayers. Using native mass spectrometry experiments we identify a pH-sensitive lipid-binding mechanism of outer membrane porin F, which enables increased threading… read more here.

Keywords: mass spectrometry; lipid binding; attenuates channel; outer membrane ... See more keywords

Resurfacing promotes antibacterial activity of a lipid A–binding nanobody

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2509305122

Abstract: Significance Antibodies have been explored to treat antibiotic-resistant infections, but identifying leads with direct antibacterial action has proven challenging. Here, we screened a library of nanobodies for antimicrobial potential and identified a nanobody that binds… read more here.

Keywords: antibacterial activity; activity lipid; promotes antibacterial; lipid binding ... See more keywords

Fungal alkaloid malbrancheamide reorients the lipid binding domain of GRK5

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recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2024.2333987

Abstract: Abstract G protein-coupled receptors (GPCRs) are the largest group of receptors involved in various types of signaling. GPCR signaling is regulated via receptor phosphorylation by G protein-coupled receptor kinases 5 (GRK5). Calmodulin (CaM), a universal… read more here.

Keywords: grk5; phosphorylation; binding domain; malbrancheamide ... See more keywords

Diversification of CD1 Molecules Shapes Lipid Antigen Selectivity

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recommendations! Published in 2021 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msab022

Abstract: Abstract Molecular studies of host–pathogen evolution have largely focused on the consequences of variation at protein–protein interaction surfaces. The potential for other microbe-associated macromolecules to promote arms race dynamics with host factors remains unclear. The… read more here.

Keywords: cd1 molecules; cd1; diversification cd1; lipid binding ... See more keywords
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Binding of DNA origami to lipids: maximizing yield and switching via strand displacement.

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recommendations! Published in 2021 at "Nucleic acids research"

DOI: 10.1093/nar/gkab888

Abstract: Liposomes are widely used as synthetic analogues of cell membranes and for drug delivery. Lipid-binding DNA nanostructures can modify the shape, porosity and reactivity of liposomes, mediated by cholesterol modifications. DNA nanostructures can also be designed… read more here.

Keywords: lipid binding; strand displacement; yield; dna ... See more keywords