Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.07.011
Abstract: Schizophrenia is a serious psychotic disorder, with disabling symptoms and markedly reduced life expectancy. The onset is usually in late adolescence or early adulthood, which in time overlaps with the maturation of the brain including… read more here.
Keywords: schizophrenia; biosynthesis; lipid biosynthesis; evidence ... See more keywords
Hacking an Algal Transcription Factor for Lipid Biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in plant science"
DOI: 10.1016/j.tplants.2017.12.008
Abstract: Transcriptional engineering is a viable means for engineering microalgae to produce lipid, but it often results in a trade-off between production and growth. A recent study shows that engineering a single transcriptional regulator enables efficient… read more here.
Keywords: biosynthesis; factor lipid; lipid biosynthesis; hacking algal ... See more keywords
Transcriptome Analysis of Genes Involved in Lipid Biosynthesis in the Developing Embryo of Pecan (Carya illinoinensis).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b00922
Abstract: Pecan (Carya illinoinensis) is an important woody tree species because of the high content of healthy oil in its nut. Thus far, the pathways and key genes related to oil biosynthesis in developing pecan seeds… read more here.
Keywords: carya illinoinensis; biosynthesis; lipid biosynthesis; biosynthesis developing ... See more keywords
Resistant starch attenuates impaired lipid biosynthesis induced by dietary oxidized oil via activation of insulin signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra08855h
Abstract: The current study found that deep-frying process led to an increased content of oxidized triacylglycerols in canola oil, 3.5 times higher than that of fresh canola oil (not used for frying). A rat model was… read more here.
Keywords: oxidized oil; group; lipid biosynthesis; resistant starch ... See more keywords
An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion
Sign Up to like & getrecommendations! Published in 2021 at "Biofabrication"
DOI: 10.1088/1758-5090/ac457c
Abstract: As the myelin sheath is crucial for neuronal saltatory conduction, loss of myelin in the peripheral nervous system (PNS) leads to demyelinating neuropathies causing muscular atrophy, numbness, foot deformities and paralysis. Unfortunately, few interventions are… read more here.
Keywords: dorsal root; root ganglion; myelin; lipid biosynthesis ... See more keywords
Phosphorylation of WRINKLED1 by KIN10 Results in Its Proteasomal Degradation, Providing a Link between Energy Homeostasis and Lipid Biosynthesis[OPEN]
Sign Up to like & getrecommendations! Published in 2017 at "Plant Cell"
DOI: 10.1105/tpc.17.00019
Abstract: A conserved sugar signaling kinase, KIN10, phosphorylates the master transcriptional activator of lipid synthesis WRINKLED1, marking it for proteasomal degradation, thereby downregulating lipid synthesis when sugar levels are low. WRINKLED1 (WRI1), a member of the… read more here.
Keywords: degradation; lipid biosynthesis; wri1; kin10 ... See more keywords
Poly(3‐hydroxybutyrate) fuels the tricarboxylic acid cycle and de novo lipid biosynthesis during Bacillus anthracis sporulation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13665
Abstract: Numerous bacteria accumulate poly(3‐hydroxybutyrate) (PHB) as an intracellular reservoir of carbon and energy in response to imbalanced nutritional conditions. In Bacillus spp., where PHB biosynthesis precedes the formation of the dormant cell type called the… read more here.
Keywords: sporulation; biosynthesis; lipid biosynthesis; cycle ... See more keywords
Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00159-23
Abstract: This work sheds new light on how P. aeruginosa limits bacterial clearance in macrophages through 2-aminoacetophenone (2-AA), a secreted signaling molecule by this pathogen that is regulated by the quorum-sensing transcription factor MvfR. The action… read more here.
Keywords: persistence; biosynthesis; lipid biosynthesis; quorum sensing ... See more keywords
Prognostic Signature and Therapeutic Value Based on Membrane Lipid Biosynthesis-Related Genes in Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/7204415
Abstract: There is a need to improve diagnostic and therapeutic approaches to enhance the prognosis of breast cancer, the most common malignancy worldwide. Membrane lipid biosynthesis is a hot biological pathway in current cancer research. It… read more here.
Keywords: model; lipid biosynthesis; cancer; membrane lipid ... See more keywords
Targeting lipid biosynthesis pathways for hepatitis B virus cure
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270273
Abstract: Chronic hepatitis B virus (HBV) infection is characterized by the presence of high circulating levels of non-infectious lipoprotein-like HBV surface antigen (HBsAg) particles thought to contribute to chronic immune dysfunction in patients. Lipid and metabolomic… read more here.
Keywords: hbv infection; hbv; lipid biosynthesis; targeting lipid ... See more keywords
Lipid Biosynthesis as an Antifungal Target
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fungi"
DOI: 10.3390/jof4020050
Abstract: Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles… read more here.
Keywords: biosynthesis antifungal; antifungal target; lipid biosynthesis; target ... See more keywords