Sirtuin 6 ameliorates bleomycin-induced pulmonary fibrosis via activation of lipid catabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31027
Abstract: Pulmonary fibrosis is a chronic and serious interstitial lung disease with little effective therapies currently. Our incomplete understanding of its pathogenesis remains obstacles in therapeutic developments. Sirtuin 6 (SIRT6) has been shown to mitigate multiple… read more here.
Keywords: bleomycin induced; pulmonary fibrosis; sirt6; fibrosis ... See more keywords
Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02077
Abstract: Amino acid sensing plays an important role in regulating lipid metabolism by sensing amino acid nutrient disturbance. T1R1 (umami taste receptor, type 1, member 1) is a membrane G protein-coupled receptor that senses amino acids.… read more here.
Keywords: tas1r1; lipid accumulation; amino acid; mice ... See more keywords
Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01294-0
Abstract: BACKGROUND Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation of cancer cells within stressed environments are still under-appreciated. We recently revealed high autophagy… read more here.
Keywords: mediated lipid; glioma; lipid catabolism; autophagy mediated ... See more keywords