Synthesis of Chemically Diverse siRNA‐Lipid Conjugates Enabled by Reversible Adsorption to Solid Support (RASS)
Sign Up to like & getrecommendations! Published in 2025 at "ChemBioChem"
DOI: 10.1002/cbic.202500169
Abstract: Small interfering RNAs (siRNAs) directly regulate gene expression and are, thus, attractive targets for clinical development to treat a variety of human diseases. While “naked” siRNAs are poor drug candidates, numerous chemical modifications of siRNAs… read more here.
Keywords: reversible adsorption; solid support; sirna lipid; lipid conjugates ... See more keywords
Synthesis of Heterotelechelic Poly(N‐ethylglycine) Polymers: from Polypeptoid Lipid Conjugates to Protein‐Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular Rapid Communications"
DOI: 10.1002/marc.202500422
Abstract: The need for alternative hydrophilic polymers to polyethylene glycol (PEG) has intensified due to increasing concerns about immunogenicity and hypersensitivity reactions. In this work, we report the synthesis of well‐defined heterotelechelic poly‐N‐ethylglycine (pNEtGly) via acid‐catalyzed… read more here.
Keywords: heterotelechelic poly; protein polymer; polymer; lipid conjugates ... See more keywords