Dual Functioned Hexapeptide-Coated Lipid-Core Nanomicelles Suppress Toll-Like Receptor-Mediated Inflammatory Responses through Endotoxin Scavenging and Endosomal pH Modulation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301230
Abstract: Excessive activation of Toll-like receptor (TLR) signaling pathways and the circulating endotoxin are key players in the pathogenesis of many acute and chronic inflammatory diseases. Regulation of TLR-mediated inflammatory responses by bioactive nanodevices represents a promising… read more here.
Keywords: core nanomicelles; like receptor; toll like; lipid core ... See more keywords
The utility of total lipid core burden index/maximal lipid core burden index ratio within the culprit plaque to predict filter-no reflow: insight from near-infrared spectroscopy with intravascular ultrasound
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1697-z
Abstract: Filter-no reflow (FNR) is a phenomenon wherein flow improves after the retrieve of distal protection. Near-infrared spectroscopy with intravascular ultrasound (NIRS–IVUS) enables lipid detection. We evaluated the predictors of FNR during PCI using NIRS–IVUS. Thirty-two… read more here.
Keywords: fnr group; index; lipid core; spectroscopy ... See more keywords
Lipid-core nanocapsules increase the oral efficacy of quercetin in cutaneous leishmaniasis
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology"
DOI: 10.1017/s003118201700097x
Abstract: SUMMARY New oral treatments are needed for all forms of leishmaniasis. Here, the improved oral efficacy of quercetin (Qc) and its penta-acetylated derivative (PQc) was evaluated in cutaneous leishmaniasis after encapsulation in lipid-core nanocapsules (LNCs)… read more here.
Keywords: efficacy quercetin; efficacy; lipid core; oral efficacy ... See more keywords
Artemether-loaded polymeric lipid-core nanocapsules reduce cell viability and alter the antioxidant status of U-87 MG cells
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2128819
Abstract: Abstract Glioblastomas are tumors that present a high mortality rate. Artemether (ART) is a lactone with antitumor properties, demonstrating low bioavailability and water solubility. In the present study, we developed lipid-core nanocapsules (LNC) containing pequi… read more here.
Keywords: antioxidant status; core nanocapsules; viability; lipid core ... See more keywords
Jak-ing Up the Plaque's Lipid Core…and Even More.
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.314074
Abstract: Until recently, many viewed atherosclerosis as a lipid storage disease or a bland accumulation of proliferated smooth muscle cells. How the landscape has changed! Abundant evidence now implicates intertwining pathways of inflammation as crucial to… read more here.
Keywords: ing plaque; core even; lipid core; jak ing ... See more keywords
Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-019-0352-4
Abstract: Background Melatonin has been described in the literature as a potent antioxidant. However, melatonin presents variable, low bioavailability and a short half-life. The use of polymeric nanoparticulated systems has been proposed for controlled release. Thus,… read more here.
Keywords: core nanocapsules; lipid peroxidation; mel lnc; lipid core ... See more keywords
Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells
Sign Up to like & getrecommendations! Published in 2017 at "Nanomaterials"
DOI: 10.3390/nano8010002
Abstract: Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, we hypothesized that self-assembling and interfacial reactions could… read more here.
Keywords: core nanocapsules; rgd mcmn; lipid core; arginylglycylaspartic acid ... See more keywords