Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010436
Abstract: Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA; 20: 3(n-6)) triggers ferroptosis in the germ cells of the… read more here.
Keywords: lipid deficiency; ferroptosis sensitivity; deficiency disrupts; ether lipid ... See more keywords
Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.03.07
Abstract: AIM To investigate the effects of different concentrations of artificial tears on lipid layer thickness (LLT) and blink rate (BR) in dry eye patients. METHODS This study included 106 eyes of 58 patients with dry… read more here.
Keywords: instillation; concentration; eye; lipid deficiency ... See more keywords
Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031884
Abstract: Inherited deficiency in ether lipids, a subgroup of glycerophospholipids with unique biochemical and biophysical properties, evokes severe symptoms in humans resulting in a multi-organ syndrome. Mouse models with defects in ether lipid biosynthesis have widely… read more here.
Keywords: lipid deficient; pathology; lipid deficiency; ether lipids ... See more keywords
Myelin lipid deficiency: a new key driver of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.343893
Abstract: Lipids play essential biological functions that include acting as components of biological membranes, energy storage, signaling, nutrients, transporters, enzyme activators, among others. Compared with the multiple research methods to assess DNA, RNA, and protein content,… read more here.
Keywords: myelin lipid; key driver; driver alzheimer; deficiency new ... See more keywords