Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor
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DOI: 10.1038/cr.2017.42
Abstract: T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-specific immune responses based on various biochemical changes of CD3 cytoplasmic domains, but the underlying structural basis remains elusive. Here we developed biophysical… read more here.
Keywords: dependent conformational; conformational dynamics; cell receptor; lipid dependent ... See more keywords
Correlation between structure and function in phosphatidylinositol lipid–dependent Kir2.2 gating
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114046119
Abstract: Significance Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels regulate cell membrane voltage by gluing two halves of a K+ channel together and opening the pore. PI(4)P competes with this process. Because both of these lipids are relatively abundant… read more here.
Keywords: function phosphatidylinositol; structure function; phosphatidylinositol; correlation structure ... See more keywords
Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
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DOI: 10.3390/ijms23115972
Abstract: Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been… read more here.
Keywords: target lipid; andrographis paniculata; lipid dependent; dependent cancer ... See more keywords