Mesoderm‐specific transcript localization in the ER and ER‐lipid droplet interface supports a role in adipocyte hypertrophy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26429
Abstract: Highly variable expression of mesoderm‐specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive association with fat mass expansion, suggests that Mest is an epigenetic determinant for the… read more here.
Keywords: mesoderm specific; specific transcript; localization; lipid droplet ... See more keywords
Melatonin protects against defects induced by malathion during porcine oocyte maturation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29189
Abstract: Malathion (MAL) is a common organophosphorus pesticide and affects both animal and human reproduction. However, the mechanisms regarding how MAL affects the mammalian oocyte quality and how to prevent it have not been fully investigated.… read more here.
Keywords: oocyte maturation; porcine; lipid droplet; malathion ... See more keywords
Measuring large lipid droplet sizes by probing restricted lipid diffusion effects with diffusion‐weighted MRS at 3T
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27651
Abstract: The in vivo probing of restricted diffusion effects in large lipid droplets on a clinical MR scanner remains a major challenge due to the need for high b‐values and long diffusion times. This work proposes… read more here.
Keywords: diffusion; droplet sizes; large lipid; lipid droplet ... See more keywords
One amino acid drives the lipid droplet targeting sequence of a new noncoding RNA-encoded protein to mitochondrion.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202200301
Abstract: Over the past decade, the majority of the mammalian genome considered to be noncoding has been revealed to be able to produce proteins. Many RNA molecules, mis-annotated as noncoding, actually are predicted to code for… read more here.
Keywords: noncoding rna; amino acid; lipid droplet; sequence ... See more keywords
Identification of Lipid Droplet Proteomes by Proximity Labeling Proteomics Using APEX2.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9537-0_5
Abstract: Lipid droplets (LDs) are ubiquitous lipid storage organelles composed of a neutral lipid core surrounded by a phospholipid monolayer that is decorated with integral and peripheral proteins. Accurate identification of LD proteins using biochemical fractionation… read more here.
Keywords: proximity labeling; lipid droplet; identification lipid; droplet proteomes ... See more keywords
DGAT1 protects against lipid induced-hepatic lipotoxicity in grass carp (Ctenopharyngodon idellus)
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.736328
Abstract: Abstract Farmed fish often suffers from fatty liver, which is characterized by the aberrant lipid accumulation. Lipid droplet is an intracellular organelle to store neutral lipid, and the formation of excessive lipid droplets in hepatocytes… read more here.
Keywords: lipid droplet; grass carp; dgat1;
Lipid droplet biogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.03.018
Abstract: Lipid droplets (LDs) store neutral lipids in their core as an energy source when nutrients are scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid monolayer, unlike other… read more here.
Keywords: droplet biogenesis; microscopy; biology; lipid droplet ... See more keywords
ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.03.026
Abstract: Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy. We tested the potential interplay between these… read more here.
Keywords: autophagy lipophagy; catabolism; hepatic lipid; sirt1 ... See more keywords
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.046
Abstract: Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced adipose-tissue inflammation,… read more here.
Keywords: tissue macrophages; tissue; lipid droplet; adipose tissue ... See more keywords
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.1016/j.devcel.2022.01.003
Abstract: Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to… read more here.
Keywords: lipid storage; lipid droplet; droplet knowledge; systematic analyses ... See more keywords
OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101252
Abstract: Summary The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not… read more here.
Keywords: lipolysis; regulation lipid; lipid droplet; droplet lipolysis ... See more keywords