Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109541
Abstract: The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss of dTBC1D22, an essential gene that encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in lipid droplet accumulation… read more here.
Keywords: lipophagy; regulation lipid; rab40; lipid homeostasis ... See more keywords
Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.11.023
Abstract: Spatial organization of phospholipid synthesis in eukaryotes is critical for cellular homeostasis. The synthesis of phosphatidylcholine (PC), the most abundant cellular phospholipid, occurs redundantly via the ER-localized Kennedy pathway and a pathway that traverses the… read more here.
Keywords: homeostasis; homeostasis maintained; biosynthesis; lipid homeostasis ... See more keywords
The Echinodermata PPAR: Functional characterization and exploitation by the model lipid homeostasis regulator tributyltin.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114467
Abstract: The wide ecological relevance of lipid homeostasis modulators in the environment has been increasingly acknowledged. Tributyltin (TBT), for instance, was shown to cause lipid modulation, not only in mammals, but also in fish, molluscs, arthropods… read more here.
Keywords: homeostasis; model lipid; lipid homeostasis; ppar rxr ... See more keywords
Alkaloids of dendrobium nobile lindl. Altered hepatic lipid homeostasis via regulation of bile acids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.111976
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Accumulation of hepatic lipid promotes systemic metabolic dysfunction and results in fatty liver. Our previous studies have shown that the alkaloids of Dendrobium nobile Lindl. (DNLA) could regulate the lipid metabolism gene expression… read more here.
Keywords: hepatic lipid; bile acids; group; lipid homeostasis ... See more keywords
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09116-x
Abstract: Transcriptional networks are critical for the establishment of tissue-specific cellular states in health and disease, including cancer. Yet, the transcriptional circuits that control carcinogenesis remain poorly understood. Here we report that Kruppel like factor 6… read more here.
Keywords: carcinoma; driven transcriptional; expression; lipid homeostasis ... See more keywords
Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00139e
Abstract: Objective: To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae. Methods: The impact of BQ exposure on wild-type and knockouts of PC biosynthesizing genes revealed the alterations in the… read more here.
Keywords: benzoquinone alters; alters lipid; saccharomyces cerevisiae; lipid homeostasis ... See more keywords
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac297
Abstract: Abstract Abnormal lipid homeostasis has been observed in the brain of Parkinson’s disease (PD) patients and experimental models, although the mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that the PD-linked protein… read more here.
Keywords: lipid homeostasis; parkinson disease; srebp2; homeostasis ... See more keywords
Autophagy Contributes to Plant Lipid Homeostasis[OPEN]
Sign Up to like & getrecommendations! Published in 2019 at "Plant Cell"
DOI: 10.1105/tpc.19.00306
Abstract: Autophagy is the conserved eukaryotic mechanism by which cytoplasmic components such as macromolecular complexes, organelles, and cytosol are degraded in the lysosome or vacuole ([Reggiori and Klionsky, 2013][1]). Basal autophagy ensures that obsolete organelles and… read more here.
Keywords: contributes plant; plant; homeostasis open; lipid homeostasis ... See more keywords
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaz4564
Abstract: APOE4-disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation. APOE4 disrupts lipid homeostasis in glia APOE4 is a strong genetic risk factor for many diseases, most… read more here.
Keywords: intracellular lipid; ipsc derived; apoe4; lipid homeostasis ... See more keywords
You are not always what you eat—Fatty acid bioconversion and lipid homeostasis in the larvae of the sand mason worm Lanice conchilega
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0218015
Abstract: The meroplanktonic larvae of benthic organisms are an important seasonal component of the zooplankton in temperate coastal waters. The larvae of the reef-building polychaete Lanice conchilega contribute up to 15% of the summer zooplankton biomass… read more here.
Keywords: bioconversion; fatty acid; larvae; lipid homeostasis ... See more keywords
GDSL lipases modulate immunity through lipid homeostasis in rice
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006724
Abstract: Lipids and lipid metabolites play important roles in plant-microbe interactions. Despite the extensive studies of lipases in lipid homeostasis and seed oil biosynthesis, the involvement of lipases in plant immunity remains largely unknown. In particular,… read more here.
Keywords: immunity; rice; plant; gdsl lipases ... See more keywords