Deoxynivalenol-induced alterations in the redox status of HepG2 cells: identification of lipid hydroperoxides, the role of Nrf2-Keap1 signaling, and protective effects of zinc
Sign Up to like & getrecommendations! Published in 2020 at "Mycotoxin Research"
DOI: 10.1007/s12550-020-00392-x
Abstract: Deoxynivalenol (DON) is a type B trichothecenes that is widely contaminating human and animal foods, leading to several toxicological implications if ingested. Induction of oxidative stress and production of lipid peroxides were suggested to be… read more here.
Keywords: nrf2 keap1; hepg2 cells; lipid hydroperoxides; hepg2 ... See more keywords
Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108847
Abstract: Lead (Pb) is one of the toxic heavy metals that have several toxicological implications including cytotoxicities and oxidative stress. The release of reactive oxygen species (ROS) usually initiates lipid peroxidation and resulting in inflammation and… read more here.
Keywords: protection; produced lipid; nrf2 keap1; hepg2 cells ... See more keywords
Lipid Hydroperoxides as Mediators of Ozone-Induced Oxidative Changes in Human Airway Epithelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.054
Abstract: Human exposure to tropospheric ozone (O3) is a significant public health concern. O3 inhalation induces airway inflammation and pulmonary function decrements, and may also lead to cardiovascular morbidity. The carbon-carbon double bonds in polyunsaturated fatty… read more here.
Keywords: epithelial cells; oxidative changes; induced oxidative; airway epithelial ... See more keywords
Insight the mechanism of ferroptosis inhibition by ferrostatin-1
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.397
Abstract: Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and hence prevented by GPx4. Ferrostatin-1 (Fer-1) inhibits ferroptosis more efficiently than phenolic antioxidants. Previous studies on the reaction of Fer-1 adopted… read more here.
Keywords: insight mechanism; ferroptosis; lipid hydroperoxides; ferrostatin ... See more keywords
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications.
Sign Up to like & getrecommendations! Published in 2023 at "Free radical research"
DOI: 10.1080/10715762.2023.2213817
Abstract: Lipid hydroperoxides (LOOHs) are reactive intermediates that arise during peroxidation of unsaturated phospholipids, glycolipids and cholesterol in biological membranes and lipoproteins. Non-physiological lipid peroxidation (LPO) typically occurs under oxidative stress conditions associated with pathologies such… read more here.
Keywords: generated lipid; lipid hydroperoxides; oxidative stress; stress generated ... See more keywords
Reactions of the Lipid Hydroperoxides With Aminic Antioxidants: The Influence of Stereoelectronic and Resonance Effects on Hydrogen Atom Transfer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00850
Abstract: Aminic radical-trapping antioxidants (RTAs), as one of the most important antioxidants, have not received sufficient attention yet. But, an increasing number of aminic RTAs have been identified as ferroptosis inhibitors in recent years, which can… read more here.
Keywords: aminic antioxidants; resonance; hydroperoxides aminic; reactions lipid ... See more keywords
Simple and Sensitive Method for the Quantitative Determination of Lipid Hydroperoxides by Liquid Chromatography/Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020229
Abstract: Lipid hydroperoxides (LOOH) are the initial products of the peroxidation of unsaturated lipids and play a crucial role in lipid oxidation due to their ability to decompose into free radicals and cause adverse effects on… read more here.
Keywords: ooh ooh; method; liquid chromatography; lipid hydroperoxides ... See more keywords
Analytical and Structural Tools of Lipid Hydroperoxides: Present State and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072139
Abstract: Mono- and polyunsaturated lipids are particularly susceptible to peroxidation, which results in the formation of lipid hydroperoxides (LOOHs) as primary nonradical-reaction products. LOOHs may undergo degradation to various products that have been implicated in vital… read more here.
Keywords: present state; lipid hydroperoxides; analytical structural; structural tools ... See more keywords