PyLipID: A Python Package for Analysis of Protein–Lipid Interactions from Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.1c00708
Abstract: Lipids play important modulatory and structural roles for membrane proteins. Molecular dynamics simulations are frequently used to provide insights into the nature of these protein–lipid interactions. Systematic comparative analysis requires tools that provide algorithms for… read more here.
Keywords: dynamics simulations; lipid interactions; protein lipid; molecular dynamics ... See more keywords
Synergistic and Competitive Lipid Interactions in the Serotonin1A Receptor Microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00422
Abstract: The interaction of lipids with G-protein-coupled receptors (GPCRs) has been shown to modulate and dictate several aspects of GPCR organization and function. Diverse lipid interaction sites have been identified from structural biology, bioinformatics, and molecular… read more here.
Keywords: serotonin1a receptor; interaction sites; lipid interactions; cholesterol ... See more keywords
Direct protein-lipid interactions shape the conformational landscape of secondary transporters
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06704-1
Abstract: Secondary transporters undergo structural rearrangements to catalyze substrate translocation across the cell membrane – yet how such conformational changes happen within a lipid environment remains poorly understood. Here, we combine hydrogen-deuterium exchange mass spectrometry (HDX-MS)… read more here.
Keywords: protein lipid; conformational landscape; direct protein; secondary transporters ... See more keywords
Reconstitution reveals how myosin-VI self-organises to generate a dynamic mechanism of membrane sculpting
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11268-9
Abstract: One enigma in biology is the generation, sensing and maintenance of membrane curvature. Curvature-mediating proteins have been shown to induce specific membrane shapes by direct insertion and nanoscopic scaffolding, while the cytoskeletal motors exert forces… read more here.
Keywords: mechanism; membrane sculpting; geometry; biology ... See more keywords
Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200884
Abstract: Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and anticancer activities, making them attractive candidates as novel therapeutics. In comparison with current antimicrobial and cancer treatments, defensins uniquely target specific… read more here.
Keywords: antimicrobial anticancer; defensin lipid; membrane targeting; lipid interactions ... See more keywords
Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein–Lipid Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Langmuir"
DOI: 10.1101/2022.12.12.520108
Abstract: The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-active lipids and proteins that enables efficient gas exchange between inhaled air and the circulation. Despite decades of advancements in the… read more here.
Keywords: lipid interactions; microscopy; lipids proteins; surfactant proteins ... See more keywords
Modeling the molecular fingerprint of protein-lipid interactions of MLKL on complex bilayers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1088058
Abstract: Lipids, the structural part of membranes, play important roles in biological functions. However, our understanding of their implication in key cellular processes such as cell division and protein-lipid interaction is just emerging. This is the… read more here.
Keywords: lipid interactions; protein lipid; molecular fingerprint; modeling molecular ... See more keywords
Insights into Polyphenol–Lipid Interactions: Chemical Methods, Molecular Aspects and Their Effects on Membrane Structures
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11141809
Abstract: Plant polyphenols have many potential applications, for example, in the fields of chemical ecology and human and animal health and nutrition. These biological benefits are related to their bioavailability, bioaccessibility and interactions with other biomolecules,… read more here.
Keywords: lipid interactions; chemical methods; polyphenol lipid; interactions chemical ... See more keywords
Lipid-lipid interactions of Escherichia coli mimetic inner membrane at human physiological temperature.
Sign Up to like & getrecommendations! Published in 2020 at "General physiology and biophysics"
DOI: 10.4149/gpb_2019063
Abstract: The current strategies to eradicate bacteria require that the antimicrobial agent either penetrate or disrupt the bacterial membrane. In Escherichia coli (E.coli) as a model of Gram-negative strains, the antimicrobials have to cross two barriers… read more here.
Keywords: inner membrane; escherichia coli; human physiological; lipid lipid ... See more keywords