Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214874120
Abstract: Adequate mass and function of adipose tissues (ATs) play essential roles in preventing metabolic perturbations. The pathological reduction of ATs in lipodystrophy leads to an array of metabolic diseases. Understanding the underlying mechanisms may benefit… read more here.
Keywords: brown white; pik3c3; adipose tissues; lipid kinase ... See more keywords
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
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DOI: 10.1242/jcs.213587
Abstract: ABSTRACT Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome… read more here.
Keywords: pikfyve; lysosome enlargement; pikfyve inhibition; inhibition ... See more keywords
ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.
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DOI: 10.2139/ssrn.4047255
Abstract: Autophagy and glycolysis are highly conserved biological processes involved in both physiological and pathological cellular programs, but the interplay between these processes is poorly understood. Here, we show that the glycolytic enzyme lactate dehydrogenase A… read more here.
Keywords: kinase activity; lipid kinase; lactylation; kinase ... See more keywords