Lipase M Is Essential for Skin Barrier Function in Mice
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DOI: 10.1111/exd.70133
Abstract: A functional skin barrier is essential for restricting water losses for terrestrial animals. The outermost layer of this barrier, the stratum corneum, consists of corneocytes (derived from terminally differentiated keratinocytes) coated with a protein‐rich envelope… read more here.
Keywords: intercellular lipid; function; lipid matrix; barrier ... See more keywords
Distribution of Drug Substances in Solid Lipid Microparticles (SLM)—Methods of Analysis and Interpretation
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DOI: 10.3390/pharmaceutics14020335
Abstract: The incorporation of drug substances into the matrix of solid lipid microparticles (SLM) is critical to providing effects such as prolonged release, taste masking, and protection of the labile API. Currently, a commonly used method… read more here.
Keywords: lipid matrix; drug substances; drug; method ... See more keywords
Lipid Biomimetic Models as Simple Yet Complex Tools to Predict Skin Permeation and Drug–Membrane Biophysical Interactions
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DOI: 10.3390/pharmaceutics16060807
Abstract: The barrier function of the skin is primarily determined by its outermost layer, the Stratum Corneum (SC). The SC consists of corneocytes embedded in a lipid matrix composed mainly of ceramides, cholesterol, and free fatty… read more here.
Keywords: simple yet; models simple; permeation; lipid matrix ... See more keywords