Concise Review: Pro-Resolving Lipid Mediators and Receptors in Stem Cell Biology.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells translational medicine"
DOI: 10.1002/sctm.19-0078
Abstract: Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and pro-healing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of… read more here.
Keywords: medicine; resolving lipid; pro resolving; lipid mediators ... See more keywords
Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1180-5
Abstract: BackgroundLyme disease or Lyme borreliosis (LB) is the commonest vector-borne disease in the North America. It is an inflammatory disease caused by the bacterium Borrelia burgdorferi. The role of the inflammatory processes mediated by prostaglandins… read more here.
Keywords: resolution; pgs related; lipid mediators; related lipid ... See more keywords
Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-022-01216-5
Abstract: Alzheimer's disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting… read more here.
Keywords: pro resolving; cerebrospinal fluid; lipid mediators; alzheimer disease ... See more keywords
Leprosy and its reactional episodes: Serum levels and possible roles of omega‐3 and omega‐6‐derived lipid mediators
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.07.008
Abstract: Graphical abstract Figure. No caption available. HighlightsLevels of eicosanoids and docosanoids on different stages of leprosy were compared.Eicosanoid levels remain stable during erythema nodosum hansenicum progression.Pro‐inflammatory lipid mediators are predominant on type‐1 (reversal) reaction.Lipid mediator… read more here.
Keywords: derived lipid; lipid mediators; leprosy reactional; reactional episodes ... See more keywords
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.024
Abstract: Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating… read more here.
Keywords: specialized pro; pro resolving; lipid mediators; myocardial infarction ... See more keywords
Building on endogenous lipid mediators to design synthetic receptor ligands.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114154
Abstract: Large numbers of diverse biologically active molecules are produced from phospholipids, the constituents of biological membranes. Indeed, many lipid-derived ligands, which can undergo inter-transformation between one and another by certain kinases or enzymes, bind to… read more here.
Keywords: synthetic receptor; building endogenous; lipid mediators; design synthetic ... See more keywords
ARACHIDONIC ACID (AA)-DERIVED LIPID MEDIATORS ARE INCREASED IN THE BONE MARROW PLASMA FROM POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA PATIENTS
Sign Up to like & getrecommendations! Published in 2020 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2020.10.197
Abstract: Arachidonic acid (AA)-derived lipid mediators like prostaglandins (PG), prostacyclins, thromboxanes (TX), leukotrienes (LT), and lipoxins (LX), are eicosanoids that act as key regulators of a wide variety of physiological responses and pathological processes. AA controls… read more here.
Keywords: lipid mediators; hete hete; group; bone marrow ... See more keywords
Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.08.006
Abstract: Rheumatoid arthritis (RA) is a disease in which joint inflammation is at the forefront but the whole body is affected, and prevention of inflammation is the main treatment approach. Lipoxins (LXs) and resolvins (Rvs) are… read more here.
Keywords: resolving lipid; levels pro; pro resolving; lipid mediators ... See more keywords
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.07.005
Abstract: Acute vascular injury occurs in a number of important clinical contexts, including spontaneous disease-related events (e.g. plaque rupture, thrombosis) and therapeutic interventions such as angioplasty, stenting, or bypass surgery. Endothelial cell (EC) disruption exposes the… read more here.
Keywords: lipid mediators; resolution vascular; vascular injury; injury specialized ... See more keywords
Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.04.026
Abstract: Neuroinflammation is a prominent feature of the response to CNS trauma. It is also an important hallmark of various neurodegenerative diseases in which inflammation contributes to the progression of pathology. Inflammation in the CNS can… read more here.
Keywords: resolution; lipid mediators; inflammation; bioactive lipid ... See more keywords
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105556
Abstract: The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. effectively ameliorates inflammation with potential as therapeutics for inflammatory diseases. However, the molecular mechanisms underlying the anti-inflammatory and inflammation-resolving features of CS are… read more here.
Keywords: anti inflammatory; specialized pro; lipid mediators; pro resolving ... See more keywords