Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2016.12.043
Abstract: Quercetin is a plant flavonoid with strong antioxidant and antiinflammatory properties interesting for skin protection. However, its poor water solubility limits its penetration and so its efficiency on skin. For this purpose, quercetin lipid nanocapsules… read more here.
Keywords: protection; antioxidant activity; formulation; lipid nanocapsules ... See more keywords
Enhanced oral bioavailability of Tanshinone IIA using lipid nanocapsules: formulation, in-vitro appraisal and pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119598
Abstract: Tanshinone IIA (TSIIA) is a promising phytomedicine that has been extensively studied due to its numerous biological activities, especially as an anticancer drug. However, it suffers from poor oral bioavailability owing to low aqueous solubility,… read more here.
Keywords: oral bioavailability; bioavailability; lncs; tanshinone iia ... See more keywords
p722 ferrocifen loaded lipid nanocapsules improve survival of murine xenografted-melanoma via a potentiation of apoptosis and an activation of CD8+ T lymphocytes.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.120111
Abstract: Metastatic melanoma is a malignant tumor with a poor prognosis. Recent new therapeutics improved the survival of patients at a metastatic stage. However, the low response rate to immunotherapy, explained in part by resistance to… read more here.
Keywords: melanoma; cd8 lymphocytes; apoptosis; lipid nanocapsules ... See more keywords
Mucoadhesive properties of liquid lipid nanocapsules enhanced by hyaluronic acid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111965
Abstract: Abstract In the field of drug delivery, nanoparticles (NPs) offer important advantages such as drug protection and solubilization, increased bioavailability, prolonged blood circulation time or sustained drug delivery. Regarding patients’ quality of life, the oral… read more here.
Keywords: lipid nanocapsules; liquid lipid; mucoadhesive properties; interaction ... See more keywords
Galenic Lab-on-a-Chip concept for lipid nanocapsules production.
Sign Up to like & getrecommendations! Published in 2021 at "Nanoscale"
DOI: 10.1039/d1nr00879j
Abstract: The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up ease induced by this… read more here.
Keywords: production; galenic lab; process; lipid nanocapsules ... See more keywords
Production of novel vitamin D3 loaded lipid nanocapsules for milk fortification
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Food Properties"
DOI: 10.1080/10942912.2016.1240690
Abstract: ABSTRACT Lipid nanoparticles are carriers to improve stability, solubility, and efficacy of bioactive compounds. In this paper, novel vitamin D3 loaded lipid nanocapsules (LNC) were produced by phase inversion method. The produced nanocapsules were characterised… read more here.
Keywords: production novel; novel vitamin; vitamin loaded; lipid nanocapsules ... See more keywords
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2139370
Abstract: ABSTRACT Objectives Baicalin is a promising anticancer nutraceutical compound, but its application is hindered by its low water solubility and bioavailability, which can be remedied by its encapsulation in nanoparticles. Methods Lipid nanocapsules (LNCs) were… read more here.
Keywords: baicalin; baicalin lncs; treatment glioma; lipid nanocapsules ... See more keywords
Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: role of PTEN/AKT signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on drug delivery"
DOI: 10.1080/17425247.2023.2216451
Abstract: OBJECTIVES Novel D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified lipid nanocapsules (LNC) were prepared with the aim of improving the effectiveness of simvastatin (SIM) in hepatocellular carcinoma (HCC). The present study, therefore, sought to investigate… read more here.
Keywords: pten akt; tpgs modified; sim; modified lipid ... See more keywords
A single intravenous injection of cyclosporin A–loaded lipid nanocapsules prevents retinopathy of prematurity
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo6638
Abstract: Retinopathy of prematurity (ROP) is a retinal disease that threatens the vision of prematurely born infants. Severe visual impairment up to complete blindness is caused by neovascularization and inflammation, progressively destroying the immature retina. ROP… read more here.
Keywords: single intravenous; rop; intravenous injection; lipid nanocapsules ... See more keywords
Targeting of immunosuppressive myeloid cells from glioblastoma patients by modulation of size and surface charge of lipid nanocapsules
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-020-00589-3
Abstract: Background Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are two of the major players involved in the inhibition of anti-tumor immune response in cancer patients, leading to poor prognosis. Selective targeting of myeloid… read more here.
Keywords: size surface; myeloid cells; charge; size ... See more keywords
Praziquantel–lipid nanocapsules: an oral nanotherapeutic with potential Schistosoma mansoni tegumental targeting
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s167285
Abstract: Purpose Lipid nanocapsules (LNCs) have shown potential to increase the bioavailability and efficacy of orally administered drugs. However, their intestinal translocation to distal target sites and their implication in pharmacokinetic (PK)–pharmacodynamic (PD) relationships are yet… read more here.
Keywords: pzq lncs; schistosoma mansoni; lipid nanocapsules; lncs ... See more keywords