Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.131
Abstract: Endothelial nitric oxide synthase (eNOS) is a membrane-anchored enzyme. To highlight the potential role and effect of membrane phospholipids on the structure and activity of eNOS, we have incorporated the recombinant oxygenase subunit of eNOS… read more here.
Keywords: endothelial nitric; oxygenase; lipid nanodiscs; oxide synthase ... See more keywords
Substrate binding in the multidrug transporter MdfA in detergent solution and in lipid nanodiscs.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.03.014
Abstract: MdfA from Escherichia coli is a prototypical secondary multi-drug (Mdr) transporter that exchanges drugs for protons. MdfA mediated drug efflux is driven by the proton gradient and enabled by conformational changes, which accompany the recruitment… read more here.
Keywords: deer; iii; lipid nanodiscs; mito tempo ... See more keywords
Lipid Nanodiscs for High-Resolution NMR Studies of Membrane Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00702
Abstract: Membrane proteins (MPs) play essential roles in numerous cellular processes. Because around 70% of the currently marketed drugs target MPs, a detailed understanding of their structure, binding properties, and functional dynamics in a physiologically relevant… read more here.
Keywords: nmr studies; high resolution; membrane proteins; lipid nanodiscs ... See more keywords
Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c17961
Abstract: Novel approaches are required to address the urgent need to develop lipid-based carriers of paclitaxel (PTX) and other hydrophobic drugs for cancer chemotherapy. Carriers based on cationic liposomes (CLs) with fluid (i.e., chain-melted) membranes (e.g.,… read more here.
Keywords: fluid lipid; peg; nanodiscsptx; fluid ... See more keywords
Lipid Nanodisc-Templated Self-Assembly of Gold Nanoparticles into Strings and Rings.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.6b08043
Abstract: Gold nanoparticles (AuNPs) exhibit strong fluorescent and electromagnetic properties, which can be enhanced upon clustering and used in therapeutic, imaging, and sensing applications. A combination of gold nanoparticles with lipid nanodiscs can be attractive for… read more here.
Keywords: self assembly; gold nanoparticles; nanodisc templated; lipid nanodiscs ... See more keywords
Detergent-free isolation of CYP450-reductase's FMN-binding domain in E. coli lipid-nanodiscs using a charge-free polymer.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07193a
Abstract: The membrane-anchored flavin mononucleotide binding domain (FBD) of CYP450 reductase was extracted in E. coli lipid-nanodiscs using charge-free pentyl-inulin polymer. FBD in nanodiscs was found to be conformationally homogenous and enabled high-resolution NMR probing. 31P… read more here.
Keywords: cyp450 reductase; nanodiscs using; binding domain; coli lipid ... See more keywords