Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303261
Abstract: Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to the success of COVID-19 mRNA vaccines (Comirnaty and Spikevax). To meet the therapeutic purpose, it is required that… read more here.
Keywords: nanoparticle lnp; lnp; therapy; lipid nanoparticle ... See more keywords
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303370
Abstract: The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA rich "bleb" structures. Here we… read more here.
Keywords: improved transfection; transfection potency; potency; lipid nanoparticle ... See more keywords
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.045
Abstract: This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected… read more here.
Keywords: active targeting; nanoparticle assemblies; methyl mannopyranoside; lipid nanoparticle ... See more keywords
Novel dandelion mannan-lipid nanoparticle: Exploring the molecular mechanism underlying the potent anticancer effect against non-small lung carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104781
Abstract: Abstract New β-branched glucomannan (TOPL) with an average molecular weight (4.29 × 104 Da) was purified from dandelion leaves for the first time. TOPL possesses a potent IC50 against non-small lung carcinoma (NSCLC); A549 and H460 cell… read more here.
Keywords: lung carcinoma; lung; mannan lipid; non small ... See more keywords
Optimizing a novel Au-grafted lipid nanoparticle through chelation chemistry for high photothermal biologic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.02.010
Abstract: Gold nanoparticles through nucleation of Au clusters have been extensively studied. However, due to low potency, prolonged tissue retention and irreversible accumulation, the safety considerations have limited their therapeutic and diagnostic applications. Novel gold nanostructures… read more here.
Keywords: gold nanoparticles; chemistry; optimizing novel; gold ... See more keywords
Lipid Nanoparticle and Liposome Reference Materials: Assessment of Size Homogeneity and Long-Term −70 °C and 4 °C Storage Stability
Sign Up to like & getrecommendations! Published in 2023 at "Langmuir"
DOI: 10.1021/acs.langmuir.2c02657
Abstract: With recent advances and anticipated proliferation of lipid nanoparticle (LNP)-delivered vaccines and therapeutics, there is a need for the availability of internationally recognized reference materials of LNP systems. Accordingly, we developed six LNP and liposome… read more here.
Keywords: long term; reference; lipid nanoparticle; size ... See more keywords
Split-Dose Administration Enhances Immune Responses Elicited by a mRNA/Lipid Nanoparticle Vaccine Expressing Respiratory Syncytial Virus F Protein.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00635
Abstract: mRNA vaccines have recently received significant attention due to their role in combating the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong humoral and cellular immune responses with acceptable safety… read more here.
Keywords: split dose; syncytial virus; immune responses; lipid nanoparticle ... See more keywords
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01501
Abstract: Mutated RAS proteins are potent oncogenic drivers and have long been considered "undruggable". While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more diverse targets. Small proteins represent… read more here.
Keywords: nanoparticle delivery; small proteins; lipid nanoparticle; delivery small ... See more keywords
Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12420
Abstract: While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle (LNP) platform to deliver mRNA-encoded peanut allergen epitopes to liver sinusoidal endothelial… read more here.
Keywords: peanut allergen; peanut; liver targeting; lipid nanoparticle ... See more keywords
A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26926-0
Abstract: Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying impurities that could affect product stability and efficacy is crucial to… read more here.
Keywords: delivery systems; mrna; lipid nanoparticle; activity ... See more keywords
Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation.
Sign Up to like & getrecommendations! Published in 2018 at "Drug research"
DOI: 10.1055/s-0044-100374
Abstract: Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes of administration due to its… read more here.
Keywords: inhaled treprostinil; lipid nanoparticle; tre; treprostinil prodrug ... See more keywords