Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202310623
Abstract: Messenger RNA (mRNA) has emerged as a promising therapeutic modality for various diseases. However, efficient delivery of mRNA into target cells remains a significant challenge. In this study, the combinatorial synthesis and characterization of a… read more here.
Keywords: mrna; delivery; lipid nanoparticle; mrna delivery ... See more keywords
Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303261
Abstract: Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to the success of COVID-19 mRNA vaccines (Comirnaty and Spikevax). To meet the therapeutic purpose, it is required that… read more here.
Keywords: nanoparticle lnp; lnp; therapy; lipid nanoparticle ... See more keywords
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303370
Abstract: The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA rich "bleb" structures. Here we… read more here.
Keywords: improved transfection; transfection potency; potency; lipid nanoparticle ... See more keywords
Ribogreen Fluorescent Assay Kinetics to Measure Ribonucleic Acid Loading into Lipid Nanoparticle Carriers
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202301083
Abstract: New generations of vaccines have been developed by encapsulating messenger ribonucleic acid (mRNA) in lipid nanoparticle (LNP) carriers. In addition to the physicochemical properties of LNPs, the encapsulation efficiency (EE) of mRNA in LNPs is… read more here.
Keywords: lipid nanoparticle; assay kinetics; ribogreen fluorescent; ribonucleic acid ... See more keywords
Lung‐Targeted Lipid Nanoparticle‐Delivered siUSP33 Attenuates SARS‐CoV‐2 Replication and Virulence by Promoting Envelope Degradation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406211
Abstract: As a structural protein of SARS‐CoV‐2, the envelope (E) protein not only plays a key role in the formation of viral particles, but also forms ion channels and has pathogenic functions, including triggering cell death… read more here.
Keywords: sars cov; replication; replication virulence; envelope ... See more keywords
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.045
Abstract: This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected… read more here.
Keywords: active targeting; nanoparticle assemblies; methyl mannopyranoside; lipid nanoparticle ... See more keywords
Novel dandelion mannan-lipid nanoparticle: Exploring the molecular mechanism underlying the potent anticancer effect against non-small lung carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104781
Abstract: Abstract New β-branched glucomannan (TOPL) with an average molecular weight (4.29 × 104 Da) was purified from dandelion leaves for the first time. TOPL possesses a potent IC50 against non-small lung carcinoma (NSCLC); A549 and H460 cell… read more here.
Keywords: lung carcinoma; lung; mannan lipid; non small ... See more keywords
Optimizing a novel Au-grafted lipid nanoparticle through chelation chemistry for high photothermal biologic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.02.010
Abstract: Gold nanoparticles through nucleation of Au clusters have been extensively studied. However, due to low potency, prolonged tissue retention and irreversible accumulation, the safety considerations have limited their therapeutic and diagnostic applications. Novel gold nanostructures… read more here.
Keywords: gold nanoparticles; chemistry; optimizing novel; gold ... See more keywords
Lipid Nanoparticle and Liposome Reference Materials: Assessment of Size Homogeneity and Long-Term −70 °C and 4 °C Storage Stability
Sign Up to like & getrecommendations! Published in 2023 at "Langmuir"
DOI: 10.1021/acs.langmuir.2c02657
Abstract: With recent advances and anticipated proliferation of lipid nanoparticle (LNP)-delivered vaccines and therapeutics, there is a need for the availability of internationally recognized reference materials of LNP systems. Accordingly, we developed six LNP and liposome… read more here.
Keywords: long term; reference; lipid nanoparticle; size ... See more keywords
Split-Dose Administration Enhances Immune Responses Elicited by a mRNA/Lipid Nanoparticle Vaccine Expressing Respiratory Syncytial Virus F Protein.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00635
Abstract: mRNA vaccines have recently received significant attention due to their role in combating the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong humoral and cellular immune responses with acceptable safety… read more here.
Keywords: split dose; syncytial virus; immune responses; lipid nanoparticle ... See more keywords
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01501
Abstract: Mutated RAS proteins are potent oncogenic drivers and have long been considered "undruggable". While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more diverse targets. Small proteins represent… read more here.
Keywords: nanoparticle delivery; small proteins; lipid nanoparticle; delivery small ... See more keywords