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   Articles with "lipid nanoparticles" as a keyword



Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery

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recommendations! Published in 2021 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202101391

Abstract: Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane‐based lipidoids named XMaNs,… read more here.

Keywords: lipid nanoparticles; delivery; acid delivery; nanoparticles broad ... See more keywords
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PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202525076

Abstract: Lipid nanoparticles (LNPs) have emerged as transformative delivery vehicles for nucleic acid therapeutics, yet their development remains heavily dependent on extensive and iterative animal testing to assess their in vivo performance. Here, PREdicting LNP In… read more here.

Keywords: animal testing; reliance animal; lipid nanoparticles; design ... See more keywords

Branched‐Tail Lipid Nanoparticles for Intravenous mRNA Delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202400225

Abstract: Lipid nanoparticles (LNPs) are proven safe and effective delivery systems on a global scale. However, their efficacy has been limited primarily to liver and immune cell targets. To extend the applicability of mRNA drugs, 580… read more here.

Keywords: lung immune; lung; delivery; cell ... See more keywords

Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202402219

Abstract: Major depressive disorder (MDD) is a prevalent mental disorder that significantly impacts social and psychological function, but no effective medication is currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of… read more here.

Keywords: like behaviors; delivery; depressive like; circatf7ip ... See more keywords

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202500605

Abstract: Prostate cancer (PCa) ranks as the fifth leading cause of cancer‐related deaths among men worldwide. In 10–20% of the cases, PCa progresses to an incurable, castration‐resistant stage. Castration‐resistant PCa cells often overexpress prostate‐specific membrane antigen… read more here.

Keywords: cancer; mrna delivery; psma; lipid nanoparticles ... See more keywords

DNA Barcoding‐Enabled Tracking of Lipid Nanoparticles: Drug‐Loading‐Dependent Biodistribution and Tumor Microenvironment Targeting

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202501914

Abstract: Lipid nanoparticles (LNPs) are versatile drug delivery systems, yet the impact of drug loading (DL) on their biodistribution and cellular uptake remains poorly understood. Optimizing drug loading is crucial for enhancing therapeutic efficacy and safety,… read more here.

Keywords: drug loading; drug; tumor; dna barcoding ... See more keywords

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System.

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recommendations! Published in 2022 at "Advanced materials"

DOI: 10.1002/adma.202201095

Abstract: Lipid nanoparticles (LNPs) are the leading non-viral technology for the delivery of exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies are exemplified by Onpattro® , an approved LNP-based RNA interference… read more here.

Keywords: lipid nanoparticles; delivery; hepatic reticuloendothelial; anionic lipid ... See more keywords

Optimizing Lipid Nanoparticles for Delivery in Primates.

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recommendations! Published in 2023 at "Advanced materials"

DOI: 10.1002/adma.202211420

Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.

Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords

Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202206187

Abstract: Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID‐19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF‐A mRNA, to ischemic tissues for producing new blood vessels is an… read more here.

Keywords: vitro; extracellular vesicles; mrna; vegf mrna ... See more keywords
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Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202301377

Abstract: Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable.… read more here.

Keywords: lipid nanoparticles; bone marrow; cd38; rna ... See more keywords

Design of PD‐L1‐Targeted Lipid Nanoparticles to Turn on PTEN for Efficient Cancer Therapy

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202309917

Abstract: Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific mRNA delivery can be achieved through modulating LNP properties, such as tuning PEGylation or varying… read more here.

Keywords: cancer; cancer therapy; lipid nanoparticles; lnps ... See more keywords