Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202101391
Abstract: Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane‐based lipidoids named XMaNs,… read more here.
Keywords: lipid nanoparticles; delivery; acid delivery; nanoparticles broad ... See more keywords
Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202201095
Abstract: Lipid nanoparticles (LNPs) are the leading non-viral technology for the delivery of exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies are exemplified by Onpattro® , an approved LNP-based RNA interference… read more here.
Keywords: lipid nanoparticles; delivery; hepatic reticuloendothelial; anionic lipid ... See more keywords
Optimizing Lipid Nanoparticles for Delivery in Primates.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211420
Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.
Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206187
Abstract: Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID‐19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF‐A mRNA, to ischemic tissues for producing new blood vessels is an… read more here.
Keywords: vitro; extracellular vesicles; mrna; vegf mrna ... See more keywords
Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301377
Abstract: Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable.… read more here.
Keywords: lipid nanoparticles; bone marrow; cd38; rna ... See more keywords
Pressure‐dependent fouling behavior during sterile filtration of mRNA‐containing lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28200
Abstract: The COVID‐19 pandemic has generated growing interest in the development of mRNA‐based vaccines and therapeutics. However, the size and properties of the lipid nanoparticles (LNPs) used to deliver the nucleic acids can lead to unique… read more here.
Keywords: sterile filtration; filtration mrna; pressure; lipid nanoparticles ... See more keywords
Comparisons between a self‐microemulsifying system and lipid nanoparticles of oxyresveratrol on the physicochemical properties and Caco‐2 cell permeability
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Lipid Science and Technology"
DOI: 10.1002/ejlt.201600053
Abstract: The lipid-based formulations including an oily self-microemulsifying drug delivery system (SMEDDS), solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC) were developed for the oral delivery of oxyresveratrol (OXYR). Each system was successfully formulated using… read more here.
Keywords: oxyr; self microemulsifying; lipid based; permeability ... See more keywords
AFM-TEM correlation microscopy and its application to lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Microscopy research and technique"
DOI: 10.1002/jemt.24336
Abstract: So far, only a few articles have demonstrated the possibility of correlated AFM-TEM imaging - sequential imaging of the same individual objects using atomic-force microscopy (AFM) and transmission electron microscopy (TEM). The current work contributes… read more here.
Keywords: application; microscopy; correlation; lipid nanoparticles ... See more keywords
Assembly and Characterization of Biocompatible Coenzyme Q10 -Enriched Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Lipids"
DOI: 10.1002/lipd.12218
Abstract: Coenzyme Q10 (CoQ10 ) is a strongly hydrophobic lipid that functions in the electron transport chain and as an antioxidant. CoQ10 was conferred with aqueous solubility by incorporation into nanoparticles containing phosphatidylcholine (PtdCho) and apolipoprotein… read more here.
Keywords: coenzyme q10; assembly characterization; coq10; lipid nanoparticles ... See more keywords
On the Structure of Solid Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201903156
Abstract: Solid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be… read more here.
Keywords: drug; structure; structure solid; lipid nanoparticles ... See more keywords
Subcellular delivery of lipid nanoparticles to endoplasmic reticulum and mitochondria.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1803
Abstract: Primarily responsible for the biogenesis and metabolism of biomolecules, endoplasmic reticulum (ER) and mitochondria are gradually becoming the targets of therapeutic modulation, whose physiological activities and pathological manifestations determine the functional capacity and even the… read more here.
Keywords: endoplasmic reticulum; biology; lipid nanoparticles; reticulum mitochondria ... See more keywords