Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.09.010
Abstract: It remains essential to decipher some of the pathological mechanisms that link obesity with deteriorating human health. Insulin resistance, due to enhanced free fatty acid substrate delivery, results in disrupted glucose homeostasis and altered mitochondrial… read more here.
Keywords: insulin; oxidative capacity; mitochondrial oxidative; lipid overload ... See more keywords
Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.81926
Abstract: During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark… read more here.
Keywords: cell; biliary epithelial; hepatic lipid; lipid overload ... See more keywords