Efficient Quantification of Lipid Packing Defect Sensing by Amphipathic Peptides: Comparing Martini 2 and 3 with CHARMM36
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c00222
Abstract: In biological systems, proteins can be attracted to curved or stretched regions of lipid bilayers by sensing hydrophobic defects in the lipid packing on the membrane surface. Here, we present an efficient end-state free energy… read more here.
Keywords: defect sensing; lipid packing; relative binding; packing defect ... See more keywords
Effect of Membrane Lipid Packing on Stable Binding of the ALPS Peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.8b00945
Abstract: The amphipathic lipid packing sensor (ALPS) motif, originally discovered on the ArfGAP1 membrane-binding protein, binds to pre-existing large packing defects in a membrane (spontaneous or due to membrane curvature), though a more precise relationship between… read more here.
Keywords: packing defects; lipid packing; alps peptide; effect ... See more keywords
Penetration and preferential binding of charged nanoparticles to mixed lipid monolayers: interplay of lipid packing and charge density.
Sign Up to like & getrecommendations! Published in 2021 at "Soft matter"
DOI: 10.1039/d0sm01945c
Abstract: Designing of nanoparticles (NPs) for biomedical applications or mitigating their cytotoxic effects requires microscopic understanding of their interactions with cell membranes. Such insight is best obtained by studying model biomembranes which, however, need to replicate… read more here.
Keywords: phase; lipid packing; penetration; charge density ... See more keywords