Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
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DOI: 10.1002/advs.202204334
Abstract: Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient delivery of messenger RNA (mRNA) to manipulate protein expression, a lipid‐peptide‐mRNA (LPm)… read more here.
Keywords: mrna; peptide; thyroid cancer; lipid peptide ... See more keywords
Preparation of Lipid-Peptide-DNA (LPD) Nanoparticles and Their Use for Gene Transfection.
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DOI: 10.1007/978-1-0716-0319-2_6
Abstract: Therapeutic gene delivery systems offer the potential for the treatment of a range of inherited and acquired inherited diseases. In contrast with viral gene vectors, the nonviral gene vectors provide a safer alternative and additional… read more here.
Keywords: lipid peptide; dna; dna lpd; peptide dna ... See more keywords
Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies
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DOI: 10.3390/pharmaceutics15020320
Abstract: Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into… read more here.
Keywords: purposes simple; peptide oligonucleotide; lipid peptide; conjugates therapeutic ... See more keywords