Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700099
Abstract: Lipid–siRNA assemblies are modified with photoresponsive polymers to enable spatiotemporally controlled silencing of interleukin 1 beta (IL1β) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts.… read more here.
Keywords: adventitial fibroblasts; lipid polymer; attenuation maladaptive; aortic adventitial ... See more keywords
Biomimetic Lipid Polymer Nanoparticles for Drug Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0319-2_4
Abstract: Biomimetic nanoparticles are hybrid nanostructures in which the uppermost layer is similar to a cell membrane. In these nanoparticles, lipids and biopolymers can be organized to improve drug incorporation and delivery. This report provides instructions… read more here.
Keywords: delivery; lipid polymer; drug; biomimetic lipid ... See more keywords
Improved oral delivery of tilianin through lipid-polymer hybrid nanoparticles to enhance bioavailability.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.004
Abstract: Tilianin (TIL) may prevent and treat myocardial ischemia reperfusion injuries. However, its oral administration is hampered by its low bioavailability. The present study aimed to formulate lipid-polymer hybrid nanoparticles (LPHNs) as carriers for the sustained… read more here.
Keywords: til lphns; til; lipid polymer; bioavailability ... See more keywords
Lipid-polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.033
Abstract: The new generation of nanoparticles (NPs) encompass attributes of lipids and polymers and are referred to as 'lipid-polymer hybrid nanoparticles' (LPHNPs). LPHNPs have helped shed light on the mechanisms involved in targeted and non-specific drug… read more here.
Keywords: cancer therapeutics; hybrid nanocarrier; lipid polymer; polymer hybrid ... See more keywords
Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.05.113
Abstract: To improve the ocular bioavailability of the strongly hydrophilic moxifloxacin hydrochloride, hyaluronic-acid-modified lipid-polymer hybrid nanoparticles (HA-LCS-NPs) were designed and characterized. An in vivo precorneal retention study in rabbits showed that the mean residence time (MRT)… read more here.
Keywords: lcs nps; lipid polymer; modified lipid; hyaluronic acid ... See more keywords
Development and optimization of methotrexate-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery applications.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.061
Abstract: Lipid-polymer hybrid nanoparticles (LPHNPs) are emerging platforms for drug delivery applications. In the present study, methotrexate loaded LPHNPs consisted of PLGA and Lipoid S100 were fabricated by employing a single-step modified nanoprecipitation method combined with… read more here.
Keywords: methotrexate; lipid polymer; delivery; polymer ... See more keywords
Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119794
Abstract: Human Immunodeficiency Virus (HIV) is a global health concern to which nanomedicine approaches provide opportunities to improve the bioavailability of existing drugs used to treat HIV.In this article, lipid polymer hybrid nanoparticles (LPHNs) were developed… read more here.
Keywords: lipid polymer; hiv; treatment; ritonavir ... See more keywords
Inhalable Formulation Based on Lipid–Polymer Hybrid Nanoparticles for the Macrophage Targeted Delivery of Roflumilast
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00576
Abstract: Here, novel lipid–polymer hybrid nanoparticles (LPHNPs), targeted to lung macrophages, were realized as potential carriers for Roflumilast administration in the management of chronic obstructive pulmonary disease (COPD). To achieve this, Roflumilast-loaded fluorescent polymeric nanoparticles, based… read more here.
Keywords: roflumilast; lipid polymer; hybrid nanoparticles; inhalable formulation ... See more keywords
Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.1c14975
Abstract: Inhaled siRNA therapy has a unique potential for treatment of severe lung diseases, such as cystic fibrosis (CF). Nevertheless, a drug delivery system tackling lung barriers is mandatory to enhance gene silencing efficacy in the… read more here.
Keywords: cystic fibrosis; sirna delivery; mucus; delivery ... See more keywords
Hydrocortisone-Loaded Lipid–Polymer Hybrid Nanoparticles for Controlled Topical Delivery: Formulation Design Optimization and In Vitro and In Vivo Appraisal
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00638
Abstract: The barrier functionalities of the skin offer a major but not insuperable hindrance for fabrication of skin delivery effective systems. This work aimed to develop an optimized lipid polymer hybrid nanoparticle and assess the skin… read more here.
Keywords: formulation; hydrocortisone; lipid polymer; polymer hybrid ... See more keywords
Herringbone-Patterned 3D-Printed Devices as Alternatives to Microfluidics for Reproducible Production of Lipid Polymer Hybrid Nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00128
Abstract: Major barriers to the implementation of nanotechnology include reproducible synthesis and scalability. Batch solution phase methods do not appear to have the potential to overcome these barriers. Microfluidic methods have been investigated as a means… read more here.
Keywords: production; lipid polymer; herringbone patterned; polymer hybrid ... See more keywords