Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13221
Abstract: Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163high CD206high tumor-associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally… read more here.
Keywords: raft; lipid raft; microenvironment; acid clinically ... See more keywords
Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202519698
Abstract: Radiotherapy failure often arises from tumor repopulation by treatment-resistant cancer cells. Following irradiation, cancer cells can undergo endoreplication to form polyploid giant cancer cells (PGCCs)-radiation-persistent cells capable of generating progeny through a virus-like asymmetric budding… read more here.
Keywords: polyploid giant; cancer; giant cancer; lipid raft ... See more keywords
The role of lipid rafts in cell entry of human metapneumovirus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25414
Abstract: Human metapneumovirus (hMPV) is a crucial pathogen in children. A cell entry is the first step for infection. Our previous study indicated that there was an endocytosis pathway for hMPV cell entry. Lipid raft is… read more here.
Keywords: hmpv; role; cell entry; entry ... See more keywords
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23308
Abstract: Ochratoxin A (OTA) is a fungal toxin that causes serious threat to human health. OTA could lead to the injury of various tissues, especially kidney injury. However, the toxic effects of OTA on human kidney… read more here.
Keywords: apoptosis; ota; human kidney; cell ... See more keywords
Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0784-z
Abstract: Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in… read more here.
Keywords: lipid raft; striatum; neutral sphingomyelinase; inhibition ... See more keywords
Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
Sign Up to like & getrecommendations! Published in 2022 at "Langmuir"
DOI: 10.1021/acs.langmuir.2c02115
Abstract: For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes.… read more here.
Keywords: coa reductase; lipid raft; hmg coa; membrane ... See more keywords
Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60032-9
Abstract: Osteoporosis is a metabolic bone disease characterized by a disruption in the balance between bone resorption and formation. The specific role and mechanism of stomatin (STOM), a major component of lipid rafts, in regulating bone… read more here.
Keywords: related stomatin; lipid raft; raft related; osteoporosis ... See more keywords
The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15128-8
Abstract: The trafficking behavior of the lipid raft-dwelling US9 protein from Herpes Simplex Virus strikingly overlaps with that of the amyloid precursor protein (APP). Both US9 and APP processing machinery rely on their ability to shuttle… read more here.
Keywords: protein; neurodegenerative disease; app processing; raft dwelling ... See more keywords
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40273
Abstract: ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that… read more here.
Keywords: raft content; abca7 regulates; abca7; nkt cell ... See more keywords
Iron-mediated interaction of alpha synuclein with lipid raft model membranes.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr00287a
Abstract: The aberrant misfolding and aggregation of alpha synuclein (αS) into toxic oligomeric species is one of the key features associated with the pathogenesis of Parkinson's disease (PD). It involves different biochemical and biophysical factors as… read more here.
Keywords: alpha synuclein; lipid raft; interaction;
Polygonatum sibiricum polysaccharide ameliorates neurotoxicity in Alzheimer disease mice by inhibiting endoplasmic reticulum stress and lipid raft formation through AMPK/GSK3β/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Neurological research"
DOI: 10.1080/01616412.2025.2559431
Abstract: BACKGROUND Polygonatum sibiricum polysaccharide (PSP) is known for its anti-inflammatory and cognitive improvement effects. However, its potential to alleviate neurotoxicity in Alzheimer's diseafse (AD) has not been thoroughly explored. This study aims to investigate the… read more here.
Keywords: mice; gsk3 nrf2; lipid raft; ampk gsk3 ... See more keywords