Lipid rafts and human diseases: why we need to target gangliosides.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13612
Abstract: Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic strategies. Beginning with a… read more here.
Keywords: need target; gbd gbd; lipid rafts; human diseases ... See more keywords
β‐elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.11023
Abstract: β‐Elemene, an anti‐cancer drug extracted from traditional Chinese medicinal herb, showed anti‐tumor effects on gastric cancer cells. Our previous studies reported gastric cancer cells are insensitive to TRAIL. However, whether β‐elemene could enhance anti‐cancer effects… read more here.
Keywords: disc lipid; gastric cancer; formation; cancer cells ... See more keywords
Self-assembly of lipid rafts revealed by fluorescence correlation spectroscopy in living breast cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biophotonics"
DOI: 10.1002/jbio.201900214
Abstract: Lipids and proteins in the plasma membrane are laterally heterogeneous and formalised as lipid rafts featuring unique biophysical properties. However, the self-assembly mechanism of lipid raft cannot be revealed even its physical properties and components… read more here.
Keywords: self assembly; correlation spectroscopy; fluorescence correlation; spectroscopy ... See more keywords
Enhancement of Lytic Activity by Leptin Is Independent From Lipid Rafts in Murine Primary Splenocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25394
Abstract: Leptin, a pleiotropic adipokine, is known as a regulator of food intake, but it is also involved in inflammation, immunity, cell proliferation, and survival. Leptin receptor is integrated inside cholesterol‐rich microdomains called lipid rafts, which,… read more here.
Keywords: lytic activity; lipid rafts; leptin; membrane remodeling ... See more keywords
Impact of lipid rafts on transient receptor potential channel activities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30679
Abstract: Members of the transient receptor potential (TRP) superfamily are cation channels that are expressed in nearly every mammalian cell type and respond as cellular sensors to various environmental stimuli. Light, pressure, osmolarity, temperature, and other… read more here.
Keywords: transient receptor; lipid rafts; receptor potential; trp channel ... See more keywords
Label‐free surface‐enhanced Raman spectroscopy of lipid‐rafts from hepatocyte plasma membranes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5101
Abstract: Lipid rafts are sphingomyelin/cholesterol-rich domains present in the plasma membrane of eukaryotic cells. In the hepatocyte, it has been shown that these domains intervene and modify a wide range of functions from which cell signaling… read more here.
Keywords: surface enhanced; spectroscopy; raman spectroscopy; lipid rafts ... See more keywords
Viral modulation of lipid rafts and their potential as putative antiviral targets
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2413
Abstract: Lipid rafts are ubiquitous in cells. They are identified as cholesterol and glycosphingolipid enriched microdomains on cellular membranes. They serve as platforms for cellular communications by functioning in signal transduction and membrane trafficking. Such structural… read more here.
Keywords: lipid rafts; modulation lipid; putative antiviral; viral modulation ... See more keywords
Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6780-3_13
Abstract: Lipid raft domains, enriched in sphingolipids and cholesterol, serve as sorting platforms and hubs for signal transduction proteins, and show resistance to detergent solubilization. Despite rafts have been involved in survival processes, these membrane domains… read more here.
Keywords: death receptor; sucrose gradient; lipid rafts; raft ... See more keywords
Use of Streptolysin O-Induced Membrane Damage as a Method of Studying the Function of Lipid Rafts During B Cell Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_17
Abstract: B-lymphocytes have the ability to repair their plasma membranes following injury, such as by bacterial cholesterol-dependent cytolysins. The repair process includes the removal of the pore from the inflicted region of the plasma membrane via… read more here.
Keywords: rafts cell; method; use streptolysin; cell activation ... See more keywords
Lipid Rafts from Olfactory Ensheathing Cells: Molecular Composition and Possible Roles
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00869-4
Abstract: Olfactory ensheathing cells (OECs) are specialized glial cells of the olfactory system, believed to play a role in the continuous production of olfactory neurons and ensheathment of their axons. Although OECs are used in therapeutic… read more here.
Keywords: olfactory ensheathing; migration; ensheathing cells; lipid rafts ... See more keywords
Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104752
Abstract: Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no… read more here.
Keywords: methyl cyclodextrin; inhibits d68; perturbing accumulation; lipid rafts ... See more keywords