Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115083119
Abstract: Significance Scramblases translocate lipids across the lipid bilayer without consumption of ATP, thereby regulating lipid distributions in cellular membranes. Cytosol-to-lumen translocation across the endoplasmic reticulum (ER) membrane is a common process among lipid glycoconjugates involved… read more here.
Keywords: glycosylphosphatidylinositol biosynthesis; efficient glycosylphosphatidylinositol; lipid scramblase; membrane ... See more keywords
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F
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DOI: 10.7554/elife.44365
Abstract: The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we… read more here.
Keywords: scramblase tmem16f; lipid scramblase; scramblase; cryo structures ... See more keywords