LC-MS Analyses of Lipid Species in Skeletal Muscle Cells and Tissue.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8897-6_12
Abstract: Liquid chromatography-mass spectrometry (LC-MS) is a widely used methodology for measuring lipids at a global level. Combined with an optimal extraction method LC-MS enables the detection and characterization of a wide range of lipid species… read more here.
Keywords: skeletal muscle; species skeletal; tissue; muscle cells ... See more keywords
Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03492-4
Abstract: Reversed-phase ultrahigh-performance liquid chromatography-mass spectrometry (RP-UHPLC/MS) method was developed with the aim to unambiguously identify a large number of lipid species from multiple lipid classes in human plasma. The optimized RP-UHPLC/MS method employed the C18… read more here.
Keywords: reversed phase; human plasma; mass; identification ... See more keywords
Diet, lipids and colon cancer.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2019.07.001
Abstract: Dietary fat is digested and absorbed in the small intestine and can then be utilized as an energy source and/or as a reservoir for other bioactive lipid species. Excessive dietary fat has been implicated in… read more here.
Keywords: dietary fat; diet lipids; lipid species; cancer ... See more keywords
Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.05.016
Abstract: The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD… read more here.
Keywords: physiological roles; systems analyses; roles genetic; analyses reveal ... See more keywords
Omic-Scale High-Throughput Quantitative LC-MS/MS Approach for Circulatory Lipid Phenotyping in Clinical Research.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02598
Abstract: Lipid analysis at the molecular species level represents a valuable opportunity for clinical applications due to the essential roles that lipids play in metabolic health. However, a comprehensive and high-throughput lipid profiling remains challenging given… read more here.
Keywords: lipid species; high throughput; omic scale; approach ... See more keywords
Effective Liquid Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry Separation of Isomeric Lipid Species.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b04979
Abstract: Lipids are a major class of molecules that play key roles in different biological processes. Understanding their biological roles and mechanisms remains analytically challenging due to their high isomeric content (e.g., varying acyl chain positions… read more here.
Keywords: spectrometry; isomeric lipid; ion mobility; trapped ion ... See more keywords
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.06.031
Abstract: The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there are no effective treatments. A decade has passed since the initial lipidomics analyses of liver tissues from patients with nonalcoholic fatty liver disease. We have… read more here.
Keywords: resolution; nonalcoholic steatohepatitis; metabolic pathways; lipid species ... See more keywords
Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918387117
Abstract: Significance Ion channels form pores that allow for the selective transport of ions across cell membranes, generating electrical signals in response to a variety of signals. Inward rectifier potassium (Kir) channels in particular are regulated… read more here.
Keywords: kir2; rectifier potassium; lipid species; membrane ... See more keywords
Platelet lipidomics: a window of opportunity to assess cardiovascular risk?
Sign Up to like & getrecommendations! Published in 2017 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx258
Abstract: Novel biomarkers that accurately report the risk of cardiovascular events such as myocardial infarction have long been sought after. This is driven by the need to inform clinical diagnostic pathways and to optimize therapeutic approaches… read more here.
Keywords: chromatography; risk; mass; cardiovascular risk ... See more keywords
Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds1[CC-BY]
Sign Up to like & getrecommendations! Published in 2017 at "Plant Physiology"
DOI: 10.1104/pp.16.01705
Abstract: The various tissue types of oilseed rape seeds have different lipid compositions, which are established early in seed development. The regulation of lipid synthesis in oil seeds is still not fully understood. Oilseed rape (Brassica… read more here.
Keywords: seed; tissue types; oilseed rape; brassica napus ... See more keywords
Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genetics"
DOI: 10.1186/s12863-017-0515-5
Abstract: BackgroundDifferential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here,… read more here.
Keywords: genetic basis; t2d; plasma lipidome; type diabetes ... See more keywords