GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11886
Abstract: Fatty acids (FAs) can promote lipid synthesis in the mammary gland via stimulating lipogenic gene expression, but the underlying molecular mechanism is still not fully understood. Here, we showed the dose‐dependent effects of palmitic acid… read more here.
Keywords: lipid synthesis; srebp; synthesis; expression ... See more keywords
Activity of a lipid synthesis inhibitor (spiromesifen) in Culiseta longiareolata (Diptera: Culicidae)
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2017.10.015
Abstract: Abstract Objective To evaluate the activity of spiromesifen against the most abundant and investigated mosquito species, Culiseta longiareolata Aitken, 1954 (Diptera, Culicidae). Methods Culiseta longiareolata larvae were collected from untreated areas located at Tebessa (Northeast… read more here.
Keywords: diptera culicidae; lipid synthesis; activity; culiseta longiareolata ... See more keywords
ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.101
Abstract: Arachidonate lipoxygenase12 (Alox12) and its metabolites 12S-hydroxyeicosatetraenoic acid (12S-HETE) have been implicated in influencing tumor transformation and progression. In this study, we have systematically evaluated the expression, function and the downstream effectors of Alox12 in… read more here.
Keywords: alox12; lipid synthesis; inhibition; breast cancer ... See more keywords
MiR-204-5p promotes lipid synthesis in mammary epithelial cells by targeting SIRT1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.10.056
Abstract: OBJECTIVES Understanding the molecular mechanisms of lipid synthesis in the mammary gland is crucial for regulating the level and composition of lipids in milk. This study aimed to investigate the functional and molecular mechanisms of… read more here.
Keywords: milk; epithelial cells; mammary epithelial; lipid synthesis ... See more keywords
Experimental and theoretical investigation of the effects of iron on growth and lipid synthesis of microalgae in view of their use to produce biofuels
Sign Up to like & getrecommendations! Published in 2021 at "Journal of environmental chemical engineering"
DOI: 10.1016/j.jece.2021.105349
Abstract: Abstract The effects of iron concentration on the growth and lipid synthesis of three microalgae strains were investigated to assess their potential to produce biofuels and/or other chemicals. The obtained results have shown that, except… read more here.
Keywords: effects iron; lipid synthesis; iron concentration; iron ... See more keywords
Concurrence in the ability for lipid synthesis between life stages in insects
Sign Up to like & getrecommendations! Published in 2017 at "Royal Society Open Science"
DOI: 10.1098/rsos.160815
Abstract: The ability to synthesize lipids is critical for an organism’s fitness; hence, metabolic pathways, underlying lipid synthesis, tend to be highly conserved. Surprisingly, the majority of parasitoids deviate from this general metabolic model by lacking… read more here.
Keywords: insects; lipid synthesis; life stages; ability ... See more keywords
Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq6288
Abstract: Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms that determine susceptibility to DNLS-targeted therapies remain unknown, and the lack… read more here.
Keywords: lipid synthesis; novo lipid; gbm; lipotoxicity ... See more keywords
Role of miR-181c in Diet-induced obesity through regulation of lipid synthesis in liver
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0256973
Abstract: We recently identified a nuclear-encoded miRNA (miR-181c) in cardiomyocytes that can translocate into mitochondria to regulate mitochondrial gene mt-COX1 and influence obesity-induced cardiac dysfunction through the mitochondrial pathway. Because liver plays a pivotal role during… read more here.
Keywords: 181c mice; obesity; lipid synthesis; liver ... See more keywords
Prolactin induces lipid synthesis of organ‐cultured pigeon crops
Sign Up to like & getrecommendations! Published in 2019 at "Poultry Science"
DOI: 10.3382/ps/pey540
Abstract: ABSTRACT The objective of this research was to examine the effects of prolactin (PRL) on the lipid synthesis of organ‐cultured pigeon crops in vitro. In experiment 1, the histology, activities of enzymes, and expression of… read more here.
Keywords: pigeon crops; organ cultured; lipid synthesis; cultured pigeon ... See more keywords
Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1007718
Abstract: Background Type I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing… read more here.
Keywords: lipid synthesis; replication; infection; samhd1 ... See more keywords
The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.942386
Abstract: The sterol regulatory-element binding protein (SREBP) family of transcription factors regulates cholesterol, fatty acid, and triglyceride synthesis and metabolism. However, they are also targeted by the ubiquitin ligase Fbw7, a major tumor suppressor, suggesting that… read more here.
Keywords: lipid synthesis; dependent regulation; synthesis; expression ... See more keywords