Association of genetically-predicted lipid traits and lipid-modifying targets with heart failure.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwac290
Abstract: AIMS To assess the association of genetically-predicted lipid traits and lipid-modification via licensed or investigational targets with heart failure (HF). METHODS AND RESULTS Two-sample Mendelian randomization (MR) study was conducted using summary-level genome-wide association studies… read more here.
Keywords: association genetically; traits lipid; genetically predicted; lipid traits ... See more keywords
Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab139
Abstract: Abstract Context Dyslipidemia is highly prevalent in youth with type 2 diabetes (T2D), yet the pathogenic components of dyslipidemia in youth with T2D are poorly understood. Objective To evaluate the genetic determinants of lipid traits… read more here.
Keywords: genome wide; lipid traits; association; type diabetes ... See more keywords
The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study.
Sign Up to like & getrecommendations! Published in 2023 at "EBioMedicine"
DOI: 10.2139/ssrn.4249783
Abstract: BACKGROUND Observational studies have investigated the effect of serum lipids on kidney function, but these findings are limited by confounding, reverse causation and have reported conflicting results. Mendelian randomization (MR) studies address this confounding problem.… read more here.
Keywords: ancestry; kidney; lipid traits; kidney function ... See more keywords
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.840579
Abstract: Objective We aimed to evaluate the causal effect of type 2 diabetes mellitus (T2DM) and glycemic traits on the risk of a wide range of cardiovascular diseases (CVDs) and lipid traits using Mendelian randomization (MR).… read more here.
Keywords: cardiovascular diseases; lipid traits; type diabetes; glycemic traits ... See more keywords
Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity
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DOI: 10.3390/genes13010091
Abstract: Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an… read more here.
Keywords: parent origin; obesity; lipid traits; blood lipid ... See more keywords
Assessment of multi-population polygenic risk scores for lipid traits in African Americans
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DOI: 10.7717/peerj.14910
Abstract: Polygenic risk scores (PRS) based on genome-wide discoveries are promising predictors or classifiers of disease development, severity, and/or progression for common clinical outcomes. A major limitation of most risk scores is the paucity of genome-wide… read more here.
Keywords: risk scores; multi population; polygenic risk; lipid traits ... See more keywords