Phase‐Separated Liposomes Hijack Endogenous Lipoprotein Transport and Metabolism Pathways to Target Subsets of Endothelial Cells In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202709
Abstract: Plasma lipid transport and metabolism are essential to ensure correct cellular function throughout the body. Dynamically regulated in time and space, the well‐characterized mechanisms underpinning plasma lipid transport and metabolism offers an enticing, but as… read more here.
Keywords: transport metabolism; metabolism pathways; transport; phase separated ... See more keywords
A programmable DNA-origami platform for studying lipid transfer between bilayers
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0325-3
Abstract: Non-vesicular lipid transport between bilayers at membrane contact sites plays important physiological roles. Mechanistic insight into the action of lipid-transport proteins localized at these sites requires determination of the distance between bilayers at which this… read more here.
Keywords: dna origami; lipid transfer; transfer; lipid transport ... See more keywords
Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1902026116
Abstract: This perspective addresses recent advances in lipid transport across the Gram-negative inner and outer membranes. While we include a summary of previously existing literature regarding this topic, we focus on the maintenance of lipid asymmetry… read more here.
Keywords: gram negative; transport; cell envelope; lipid transport ... See more keywords
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1232
Abstract: Abstract Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small interfering RNAs (siRNAs). However,… read more here.
Keywords: hydrophobicity drives; lipid transport; hydrophobicity; lipid sirnas ... See more keywords
Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad238
Abstract: Heterotrimeric GTP-binding proteins (G proteins) are a group of regulators essential for signal transmission into cells. Regulator of G-protein signaling 1 (AtRGS1) possesses intrinsic GTPase-accelerating protein (GAP) activity and could suppress G-protein and glucose signal… read more here.
Keywords: signaling facilitating; transport protein; protein orp2a; degradation ... See more keywords
Lipid Transport Across Bacterial Membranes.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-120420-022914
Abstract: The movement of lipids within and between membranes in bacteria is essential for building and maintaining the bacterial cell envelope. Moving lipids to their final destination is often energetically unfavorable and does not readily occur… read more here.
Keywords: across bacterial; bacterial membranes; biology; transport across ... See more keywords
Lipid metabolic reprogramming extends beyond histological tumor demarcations in operable human pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0396
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of… read more here.
Keywords: lipid metabolic; pancreatic cancer; tumor; lipid transport ... See more keywords
A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259357
Abstract: ABSTRACT At organelle–organelle contact sites, proteins have long been known to facilitate the rapid movement of lipids. Classically, this lipid transport involves the extraction of single lipids into a hydrophobic pocket on a lipid transport… read more here.
Keywords: bulk lipid; membrane expansion; lipid transport;
Non-vesicular lipid transport machinery in Trichomonas vaginalis: novel drug targets against Trichomoniasis.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666221220124443
Abstract: Eukaryotic cells have separate membrane-enclosed organelles with distinct biochemical identities and specialized functions. The unique characteristics of each organelle are regulated by asymmetric distribution and intra-cellular trafficking of two important biomolecules, proteins and lipids. Non-vesicular… read more here.
Keywords: non vesicular; transport; transport machinery; trichomonas ... See more keywords
ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.988014
Abstract: Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange of ions, metabolites and lipids and membrane dynamics. Cataloguing MCS revolutionized our understanding of… read more here.
Keywords: contact sites; sites multifaceted; multifaceted factory; mitochondria contact ... See more keywords
Change in the Lipid Transport Capacity of the Liver and Blood during Reproduction in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00517
Abstract: To support the high energetic demands of reproduction, female mammals display plasticity in many physiological processes, such as the lipid transport system. Lipids support the energy demands of females during reproduction, and energy and structural… read more here.
Keywords: reproduction; transport; lactation; lipid transport ... See more keywords