Caveolin-1 facilitates lipid uptake into endothelium by stabilizing Cd36 at the plasma membrane
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732697
Abstract: Endothelial cells (ECs) can take up lipids from the circulation through Caveolin-1 (Cav1)-mediated endocytosis. In metabolic disease, fatty acids accumulate in blood plasma, creating a pathological role for ECs as lipid metabolizing cells. ScRNAseq performed… read more here.
Keywords: membrane; endothelium; cav1; microscopy ... See more keywords
Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-1147
Abstract: De novo lipogenesis is a well-described androgen receptor (AR)–regulated metabolic pathway that supports prostate cancer tumor growth by providing fuel, membrane material, and steroid hormone precursor. In contrast, our current understanding of lipid supply from… read more here.
Keywords: cancer; prostate cancer; lipid uptake; disease ... See more keywords
Abelmoschus esculentus subfractions ameliorate hepatic lipogenesis and lipid uptake via regulating dipeptidyl peptidase-4—With improving insulin resistance
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265444
Abstract: Nonalcoholic fatty liver disease (NAFLD) is recognized as the liver component of metabolic syndrome. The regulation of hepatic lipid should be emphasized to prevent accompanying illness. As AMP-activated protein kinase (AMPK) and sterol regulatory element… read more here.
Keywords: dipeptidyl peptidase; insulin resistance; hepatic lipogenesis; lipid uptake ... See more keywords
TDP43 Exacerbates Atherosclerosis Progression by Promoting Inflammation and Lipid Uptake of Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.687169
Abstract: Objective Atherosclerosis (AS), characterized by cholesterol overloaded-macrophages accumulation and plaque formation in blood vessels, is the major cause of cardiovascular disease. Transactive response DNA-binding protein∼43 kDa (TDP43) has recently been identified as an independent driver… read more here.
Keywords: uptake macrophages; response; dna; tdp43 ... See more keywords
Nε-(carboxymethyl)lysine promotes lipid uptake of macrophage via cluster of differentiation 36 and receptor for advanced glycation end products
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Diabetes"
DOI: 10.4239/wjd.v14.i3.222
Abstract: BACKGROUND Advanced glycation end products (AGEs) are diabetic metabolic toxic products that cannot be ignored. Nε-(carboxymethyl)lysine (CML), a component of AGEs, could increase macrophage lipid uptake, promote foam cell formation, and thereby accelerate atherosclerosis. The… read more here.
Keywords: cml; receptor; cd36 rage; lipid uptake ... See more keywords