Genetically Encoded Inverse Bolaamphiphiles.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b01380
Abstract: Developing new protein-based materials with a programmable assembly is of great scientific interest and technological importance. Inspired by nature's use of post-translational modifications (PTMs) to control the function and location of proteins, we have leveraged… read more here.
Keywords: protein; encoded inverse; lipidation; genetically encoded ... See more keywords
The Biosynthesis and Applications of Protein Lipidation.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.4c00419
Abstract: Protein lipidation dramatically affects protein structure, localization, and trafficking via remodeling protein-membrane and protein-protein interactions through hydrophobic lipid moieties. Understanding the biosynthesis of lipidated proteins, whether natural ones or mimetics, is crucial for reconstructing, validating,… read more here.
Keywords: protein lipidation; applications protein; biosynthesis applications; lipidation ... See more keywords
S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00161
Abstract: Lipidation of peptides is a promising means of modification that can improve the therapeutic character of biologically active peptides. Here, a novel lipidation protocol for peptides is described. The C-H sulfenylation of indole in peptides… read more here.
Keywords: modification; tryptophan selective; peptide lipidation; lipidation ... See more keywords
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01759-7
Abstract: Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes. Among these, protein lipidations which refer to lipid attachment to proteins are prominent, which primarily encompassing… read more here.
Keywords: disease; protein lipidations; protein lipidation; lipidation health ... See more keywords
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63625-6
Abstract: Lipid-anchored proteins are integral components of cell surfaces. In bacteria, lipidation of proteins with a conserved lipobox motif ([L/V/I]−3 [A/S/T/V/I]−2 [G/A/S]−1 [C]+1) is catalyzed by prolipoprotein diacylglyceryl transferase (Lgt). Although lipobox-containing proteins, or lipoproteins, are… read more here.
Keywords: archaeal; physiology; cell; lipidation ... See more keywords
Late-stage lipidation of peptides via aqueous thiol-michael addition to dehydroalanine (Dha).
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc01085c
Abstract: This work presents a late-stage aqueous peptide lipidation strategy via the thiol-Michael addition of thiolated lipids at dehydroalanine (Dha). This strategy was used to synthesise lipopeptides containing diacylglycerol (DAG), saturated, unsaturated and cholesterol lipid motifs.… read more here.
Keywords: thiol michael; dehydroalanine dha; michael addition; lipidation ... See more keywords
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1525476
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened… read more here.
Keywords: protein; atg7; lipidation; cancer ... See more keywords
Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2062889
Abstract: LC3 lipidation-mediated selective macroautophagy/autophagy helps eukaryotes to defend against endogenous dangers and foreign invaders. However, LC3 activation mechanisms of selective autophagy are still elusive. We previously determined that the V-ATPase-ATG16L1 axis is critical for LC3… read more here.
Keywords: lipidation; lc3 lipidation; sensing atpase; damage sensing ... See more keywords
High‐density lipoprotein mimetic peptide 4F mitigates amyloid‐β‐induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14554
Abstract: The apolipoprotein E (apoE) ε4 allele is the primary genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once secreted from these cells, apoE binds lipids and… read more here.
Keywords: high density; lipidation; secretion lipidation; mimetic peptide ... See more keywords
Effect of Lipidation on the Localization and Activity of a Lysozyme Inhibitor in Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00633-19
Abstract: Neisseria gonorrhoeae is one of many bacterial species that express multiple lysozyme inhibitors. It is unclear how inhibitors that differ in their subcellular localization contribute to defense from lysozyme. We investigated how lipidation of SliC,… read more here.
Keywords: lysozyme; lipidation; localization; lysozyme inhibitor ... See more keywords
Lipoprotein Processing and Sorting in Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00911-20
Abstract: Bacterial lipoproteins have diverse roles in multiple aspects of bacterial physiology, antimicrobial resistance, and pathogenesis. Dedicated pathways direct the posttranslational lipidation and localization of lipoproteins, but there is considerable variation in these pathways among the… read more here.
Keywords: lipidation; pylori; helicobacter pylori; physiology ... See more keywords