Genetically Encoded Inverse Bolaamphiphiles.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b01380
Abstract: Developing new protein-based materials with a programmable assembly is of great scientific interest and technological importance. Inspired by nature's use of post-translational modifications (PTMs) to control the function and location of proteins, we have leveraged… read more here.
Keywords: protein; encoded inverse; lipidation; genetically encoded ... See more keywords
S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00161
Abstract: Lipidation of peptides is a promising means of modification that can improve the therapeutic character of biologically active peptides. Here, a novel lipidation protocol for peptides is described. The C-H sulfenylation of indole in peptides… read more here.
Keywords: modification; tryptophan selective; peptide lipidation; lipidation ... See more keywords
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1525476
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened… read more here.
Keywords: protein; atg7; lipidation; cancer ... See more keywords
Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2062889
Abstract: LC3 lipidation-mediated selective macroautophagy/autophagy helps eukaryotes to defend against endogenous dangers and foreign invaders. However, LC3 activation mechanisms of selective autophagy are still elusive. We previously determined that the V-ATPase-ATG16L1 axis is critical for LC3… read more here.
Keywords: lipidation; lc3 lipidation; sensing atpase; damage sensing ... See more keywords
High‐density lipoprotein mimetic peptide 4F mitigates amyloid‐β‐induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14554
Abstract: The apolipoprotein E (apoE) ε4 allele is the primary genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once secreted from these cells, apoE binds lipids and… read more here.
Keywords: high density; lipidation; secretion lipidation; mimetic peptide ... See more keywords
Effect of Lipidation on the Localization and Activity of a Lysozyme Inhibitor in Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00633-19
Abstract: Neisseria gonorrhoeae is one of many bacterial species that express multiple lysozyme inhibitors. It is unclear how inhibitors that differ in their subcellular localization contribute to defense from lysozyme. We investigated how lipidation of SliC,… read more here.
Keywords: lysozyme; lipidation; localization; lysozyme inhibitor ... See more keywords
Lipoprotein Processing and Sorting in Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00911-20
Abstract: Bacterial lipoproteins have diverse roles in multiple aspects of bacterial physiology, antimicrobial resistance, and pathogenesis. Dedicated pathways direct the posttranslational lipidation and localization of lipoproteins, but there is considerable variation in these pathways among the… read more here.
Keywords: lipidation; pylori; helicobacter pylori; physiology ... See more keywords
Lipidation Approaches Potentiate Adjuvant-Pulsed Immune Surveillance: A Design Rationale for Cancer Nanovaccine
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00787
Abstract: Adjuvant-pulsed peptide vaccines hold great promise for the prevention and treatment of different diseases including cancer. However, it has been difficult to maximize vaccine efficacy due to numerous obstacles including the unfavorable tolerability profile of… read more here.
Keywords: lipidation approaches; lipidation; adjuvant pulsed; approaches potentiate ... See more keywords
Protein Lipidation Types: Current Strategies for Enrichment and Characterization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042365
Abstract: Post-translational modifications regulate diverse activities of a colossal number of proteins. For example, various types of lipids can be covalently linked to proteins enzymatically or non-enzymatically. Protein lipidation is perhaps not as extensively studied as… read more here.
Keywords: strategies enrichment; current strategies; protein lipidation; lipidation ... See more keywords
Influence of Lipidation Pattern of the KR12 Fragment of Peptide LL-37 on Its Antibacterial and Hemolytic Activities
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065505
Abstract: Contemporary medicine has been confronted by multidrug resistance. Therefore, new antibiotics are sought to alleviate the problem. In this study, we estimated the effect of the positioning and extent of lipidation (mainly octanoic acid residue)… read more here.
Keywords: hemolytic activities; ch2 ch2; kr12 nh2; lipidation ... See more keywords