Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0483-7
Abstract: AbstractLipidomics, which reveals comprehensive characterization of molecular lipids, is a rapidly growing technology used in biomedical research. Lipid extraction is a critical step in lipidomic analysis. However, the effectiveness of different lipid extract solvent systems… read more here.
Keywords: extraction; lipid extraction; lipidomic analysis; uhplc esi ... See more keywords
Lipidomic analysis of single and combined effects of polyethylene microplastics and polychlorinated biphenyls on human hepatoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126777
Abstract: Microplastics are an emerging environmental issue as a result of their ubiquity, persistence, and intrinsic toxic potential. In addition, their ability to sorb and transport a wide variety of environmental pollutants (i.e. "Trojan Horse" effect)… read more here.
Keywords: combined effects; lipidomic analysis; human hepatoma; single combined ... See more keywords
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.028
Abstract: In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in… read more here.
Keywords: lipidomic analysis; parkinson; stearoyl coa; neurotoxicity ... See more keywords
Lipidomic analysis of diatoms cultivated with silica nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2020.112452
Abstract: Polar lipids from the diatoms Diadesmis gallica and Navicula atomus were separated and their structures were determined using high resolution tandem MS HILIC-LC/ESI. This method allowed us to identify 34 classes of lipids, each containing… read more here.
Keywords: lipidomic analysis; cultivated silica; analysis diatoms; silica nanoparticles ... See more keywords
Serum lipidomic analysis for the discovery of biomarkers for major depressive disorder in drug-free patients
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.04.029
Abstract: Lipidomic analysis can be used to efficiently identify hundreds of lipid molecular species in biological materials and has been recently established as an important tool for biomarker discovery in various neuropsychiatric disorders including major depressive… read more here.
Keywords: depressive disorder; lipidomic analysis; analysis; major depressive ... See more keywords
Comprehensive-targeted lipidomic analysis in Niemann-Pick C disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2021.11.005
Abstract: Niemann-Pick C disease (NPC) is a lysosomal disease caused by mutations in NPC1 or NPC2 genes responsible for intracellular accumulation of free cholesterol and glycosphingolipids in a variety of tissues. We collected plasma samples from… read more here.
Keywords: lipidomic analysis; analysis; disease; comprehensive targeted ... See more keywords
Four-Dimensional Lipidomic Analysis Using Comprehensive Online UHPLC × UHPSFC/Tandem Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2024 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.4c03946
Abstract: Multidimensional chromatography offers enhanced chromatographic resolution and peak capacity, which are crucial for analyzing complex samples. This study presents a novel comprehensive online multidimensional chromatography method for the lipidomic analysis of biological samples, combining lipid… read more here.
Keywords: tandem mass; analysis; analysis using; comprehensive online ... See more keywords
Comparative Lipidomic Analysis Reveals the Lactational Changes in the Lipid Profiles of Chinese Human Milk.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08857
Abstract: Human milk (HM) lipid plays a crucial role in infant development, whereas its complex lipid profiles and its dynamic changes during prolonged lactation have not been investigated yet. Comparative lipidomic analyses were employed in investigating… read more here.
Keywords: human milk; comparative lipidomic; milk; lipidomic analysis ... See more keywords
Lipidomic Analysis of Extracellular Vesicles in Human Breast Milk and Comparison with Milk Polar Lipids Using Ultraperformance Supercritical Fluid Chromatography-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c01263
Abstract: Milk-derived extracellular vesicles (EVs) show potential applications as nanomedicine; however, their membrane lipids are not fully studied. Herein, we present the lipidomic analysis of the extracted EVs and milk fat globules (MFGs) from human breast… read more here.
Keywords: extracellular vesicles; breast milk; lipidomic analysis; human breast ... See more keywords
Lipidomic analysis as a tool for identifying susceptibility to various skin diseases
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00364a
Abstract: This review is about the significance of the use of lipidomic analysis for identifying susceptibility to skin diseases. read more here.
Keywords: identifying susceptibility; skin diseases; lipidomic analysis;
Lipidomic analysis of facial skin surface lipids in acne in young women
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cosmetic Science"
DOI: 10.1111/ics.12942
Abstract: Alterations in the secretion and composition of skin surface lipids (SSL) are closely associated with the development of acne. Lipidomics is a useful tool to analyse the SSL of different types of acne. Our previous… read more here.
Keywords: skin surface; lipidomic analysis; facial skin; surface lipids ... See more keywords