Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP
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DOI: 10.1038/s41556-018-0270-5
Abstract: Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general response to mechanical signals delivered… read more here.
Keywords: extracellular matrix; matrix; mechanical cues; lipin ... See more keywords
301-OR: Lipin 1–Mediated Phosphatidic Acid Phosphatase Activity in Adipocytes Regulates Systemic Insulin Sensitivity on High-Fat Diet
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DOI: 10.2337/db20-301-or
Abstract: Emerging evidence suggests that the capacity of adipocytes to appropriately store lipids and prevent their ectopic accumulation in liver and skeletal muscle may be an important regulator of systemic insulin sensitivity. Lipin 1 is a… read more here.
Keywords: lipin; adn lpin1; mice; insulin sensitivity ... See more keywords