Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes.
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DOI: 10.1021/acs.bioconjchem.8b00585
Abstract: Sequence-defined cationic lipo-oligomers are potent siRNA carriers, forming stable lipo-polyplexes based on both electrostatic and hydrophobic interactions and, after endocytosis and endosomal protonation, facilitating the delivery of siRNA into the cytosol. After completion of the… read more here.
Keywords: lipo oligomers; cleavage; cleavage sites; enzymatic cleavage ... See more keywords