Shedding light on human cerebral lipofuscin: An explorative study on identification and quantification
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24971
Abstract: Increased oxidative stress has been associated with several neurodegenerative diseases such as Alzheimer's disease, but also with neurological diseases sharing pathophysiological pathways like epilepsy. Lipofuscin is a nondegradable end‐product of oxidative stress; its cerebral presence… read more here.
Keywords: lipofuscin; study; shedding light; quantification ... See more keywords
Impact of the age-related protein aggregate lipofuscin on β-cell functionality
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.247
Abstract: The formation of cross-linked protein aggregates such as lipofuscin is a typical hallmark of cellular aging and especially affects long-living and postmitotic cells such as neurons and skeletal muscle cells. Lipofuscin can neither be degraded… read more here.
Keywords: age; impact; cell functionality; lipofuscin ... See more keywords
Lipofuscin: a key compound in ophthalmic practice
Sign Up to like & getrecommendations! Published in 2021 at "Romanian Journal of Ophthalmology"
DOI: 10.22336/rjo.2021.23
Abstract: Lipofuscin is an intracellular aging pigment with fluorescent properties, found in retinal pigment epithelium cells of the eye. It is the main fluorophore used in fundus autofluorescence imaging techniques to diagnose, describe, and follow retinal… read more here.
Keywords: lipofuscin key; lipofuscin; disease; compound ophthalmic ... See more keywords
Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010222
Abstract: Age-related macular degeneration (AMD) is the primary cause of central blindness among the elderly. AMD is associated with progressive accumulation of lipofuscin granules in retinal pigment epithelium (RPE) cells. Lipofuscin contains bisretinoid fluorophores, which are… read more here.
Keywords: lipofuscin; oxidation; oxidation products; bisretinoid oxidation ... See more keywords