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   Articles with "lipofuscin" as a keyword



Shedding light on human cerebral lipofuscin: An explorative study on identification and quantification

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recommendations! Published in 2020 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.24971

Abstract: Increased oxidative stress has been associated with several neurodegenerative diseases such as Alzheimer's disease, but also with neurological diseases sharing pathophysiological pathways like epilepsy. Lipofuscin is a nondegradable end‐product of oxidative stress; its cerebral presence… read more here.

Keywords: lipofuscin; study; shedding light; quantification ... See more keywords

Impact of the age-related protein aggregate lipofuscin on β-cell functionality

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.04.247

Abstract: The formation of cross-linked protein aggregates such as lipofuscin is a typical hallmark of cellular aging and especially affects long-living and postmitotic cells such as neurons and skeletal muscle cells. Lipofuscin can neither be degraded… read more here.

Keywords: age; impact; cell functionality; lipofuscin ... See more keywords

Toward Systemic Lipofuscin Removal

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recommendations! Published in 2024 at "Rejuvenation Research"

DOI: 10.1089/rej.2024.0034

Abstract: Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of postmitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor… read more here.

Keywords: lipofuscin removal; toward systemic; cell; lipofuscin ... See more keywords

An optimised protocol for the detection of lipofuscin, a versatile and quantifiable marker of cellular senescence

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0306275

Abstract: Lipofuscin is a yellow-brown pigment typically found in the lysosomes that contains a mixture of molecules including lipids, metals and misfolded proteins. The use of Sudan black B to detect lipofuscin accumulation, a well described… read more here.

Keywords: senescence; detection; cellular senescence; optimised protocol ... See more keywords

Lipofuscin: a key compound in ophthalmic practice

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recommendations! Published in 2021 at "Romanian Journal of Ophthalmology"

DOI: 10.22336/rjo.2021.23

Abstract: Lipofuscin is an intracellular aging pigment with fluorescent properties, found in retinal pigment epithelium cells of the eye. It is the main fluorophore used in fundus autofluorescence imaging techniques to diagnose, describe, and follow retinal… read more here.

Keywords: lipofuscin key; lipofuscin; disease; compound ophthalmic ... See more keywords

Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23010222

Abstract: Age-related macular degeneration (AMD) is the primary cause of central blindness among the elderly. AMD is associated with progressive accumulation of lipofuscin granules in retinal pigment epithelium (RPE) cells. Lipofuscin contains bisretinoid fluorophores, which are… read more here.

Keywords: lipofuscin; oxidation; oxidation products; bisretinoid oxidation ... See more keywords