NMR chiral recognition of lipoic acid by cinchonidine CSA: A stereocenter beyond the organic function.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23514
Abstract: Alpha-lipoic acid is a natural product that possesses distinct pharmacological properties. Lipoic acid is a short-chain fatty acid containing an asymmetric carbon at five bonds of distance to the organic function. Herein, we developed a… read more here.
Keywords: lipoic acid; organic function; lipoic; chiral recognition ... See more keywords
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4213
Abstract: With the growth of the aging population, the prevalence of Alzheimer's disease (AD) has increased and influenced the work and daily life of AD patients, imposing a heavy burden on society and the patients' families.… read more here.
Keywords: pc12 cells; lipoic acid; alpha lipoic; disease ... See more keywords
Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential
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DOI: 10.1007/s00011-017-1079-6
Abstract: BackgroundThe molecular nature of lipoic acid (LA) clarifies its capability of taking part to a variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is the antioxidant activity due to… read more here.
Keywords: biochemical clinical; several diseases; activity; lipoic acid ... See more keywords
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1509-1
Abstract: Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From… read more here.
Keywords: depression; dvs20; cort; alpha lipoic ... See more keywords
Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid
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DOI: 10.1007/s11010-018-3363-3
Abstract: Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes, which is a serious health problem worldwide. This study investigates the anti-aging, anti-apoptotic, and antioxidant properties of alpha-lipoic acid (ALA),… read more here.
Keywords: oxidative stress; aging oxidative; stress; alpha lipoic ... See more keywords
The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04173-7
Abstract: Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity. This study aimed to investigate the influence of alpha lipoic… read more here.
Keywords: fibrosis; hepatic injury; pulmonary fibrosis; alpha lipoic ... See more keywords
Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain
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DOI: 10.1007/s11356-017-0158-0
Abstract: To explore the protective efficacy of α-lipoic acid (ALA) against Cd-prompted neurotoxicity, young male New Zealand rabbits (Oryctolagus cuniculus) were divided randomly into four groups. Group 1 (control) received demineralized water. Group 2 (Cd) administered… read more here.
Keywords: group; cadmium; efficacy lipoic; brain ... See more keywords
Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia
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DOI: 10.1007/s11596-019-2124-1
Abstract: The aim of the present study was to observe the protective effects of α-lipoic acid (ALA) on vascular injury in rats with hyperuricemia (HUA). The ALA treatment groups (10, 30 and 90 mg/kg, respectively) were… read more here.
Keywords: effects lipoic; ala; rats hyperuricemia; ala groups ... See more keywords
Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria.
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DOI: 10.1007/s12011-021-02712-3
Abstract: Arsenic as a heavy metal and toxic pollutant has been established that has the hepatotoxic effect in animal and human models. Previous studies showed that mitochondria as the first target of arsenic toxicity has a… read more here.
Keywords: induced oxidative; mitochondria; arsenic induced; alpha lipoic ... See more keywords
Effect of Lipoic Acid on the Biochemical Mechanisms of Resistance to Bortezomib in SH-SY5Y Neuroblastoma Cells
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DOI: 10.1007/s12035-017-0575-6
Abstract: Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin,… read more here.
Keywords: cell viability; effect; btz; stress ... See more keywords
Alpha Lipoic Acid Supplementation Improves Ovarian Tissue Vitrification Outcome: An Alternative to Preserve the Ovarian Function of Morada Nova Ewe
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DOI: 10.1007/s43032-021-00593-4
Abstract: This study evaluated the effect of adding alpha lipoic acid (ALA) to the vitrification solution of sheep ovarian tissue on 7 days of in vitro culture or 15 days of xenotransplantion. ALA was used at… read more here.
Keywords: ovarian tissue; tissue; alpha lipoic; culture ... See more keywords