Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance
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DOI: 10.1126/science.abn4213
Abstract: Emerging resistance to currently used antibiotics is a global public health crisis. Because most of the biosynthetic capacity within the bacterial kingdom has remained silent in previous antibiotic discovery efforts, uncharacterized biosynthetic gene clusters found… read more here.
Keywords: lipopeptide antibiotic; prospecting synthesis; resistance; bioinformatic prospecting ... See more keywords
More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin
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DOI: 10.3390/antibiotics9010017
Abstract: Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections, bacteremia, and right-sided endocarditis caused… read more here.
Keywords: membrane active; pore current; lipopeptide antibiotic; current perspective ... See more keywords