Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109541
Abstract: The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss of dTBC1D22, an essential gene that encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in lipid droplet accumulation… read more here.
Keywords: lipophagy; regulation lipid; rab40; lipid homeostasis ... See more keywords
Ellagitannins-Derived Intestinal Microbial Metabolite Urolithin A Ameliorates Fructose-Driven Hepatosteatosis by Suppressing Hepatic Lipid Metabolic Reprogramming and Inducing Lipophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05776
Abstract: Excessive fructose consumption exacerbates the progression of nonalcoholic fatty liver disease (NAFLD) by disrupting hepatic lipid homeostasis. This study sought to evaluate the efficacy of urolithin A (UroA) in a fructose-induced NAFLD mouse model. UroA… read more here.
Keywords: fructose fed; lipophagy; hepatic lipid; metabolic reprogramming ... See more keywords
SQSTM1, lipid droplets and current state of their lipophagy affairs
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2094606
Abstract: ABSTRACT SQSTM1/p62 (sequestosome 1) is a well-established indicator of macroautophagic/autophagic flux. It was initially characterized as the ubiquitin-binding autophagic receptor in aggrephagy, the selective autophagy of ubiquitinated protein aggregates. Recently, several studies correlated its levels… read more here.
Keywords: lipid droplets; lipophagy; selective autophagy; sqstm1 ... See more keywords
Paradoxical feeding activation of gut lipophagy by FGF15/FGF19-NR0B2/SHP-TFEB
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2108296
Abstract: ABSTRACT Macroautophagic/autophagic degradation of lipid droplets, lipophagy, is activated by fasting but repressed by feeding. Surprisingly, our recent study showed that this is not the case in the gut, where feeding activates lipophagy, reducing intestinal… read more here.
Keywords: gut; lipophagy; nr0b2 shp; activation ... See more keywords
Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.02020-16
Abstract: ABSTRACT Robust dengue virus (DENV) replication requires lipophagy, a selective autophagy that targets lipid droplets. The autophagic mobilization of lipids leads to increased β-oxidation in DENV-infected cells. The mechanism by which DENV induces lipophagy is… read more here.
Keywords: dengue virus; lipophagy; denv; induction ... See more keywords
Lipophagy: A Potential Therapeutic Target for Diabetic Nephropathy.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220727113129
Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and one of the main causes of end-stage renal disease (ESRD). There are many factors causing the progression of DN. Lipid metabolism disorder is a… read more here.
Keywords: therapeutic target; lipophagy potential; lipophagy; potential therapeutic ... See more keywords
The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1124003
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid… read more here.
Keywords: alcoholic fatty; non alcoholic; fatty liver; disease ... See more keywords
Nitrogen Starvation and Stationary Phase Lipophagy Have Distinct Molecular Mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239094
Abstract: In yeast, the selective autophagy of intracellular lipid droplets (LDs) or lipophagy can be induced by either nitrogen (N) starvation or carbon limitation (e.g., in the stationary (S) phase). We developed the yeast, Komagataella phaffii… read more here.
Keywords: phase; phase lipophagy; stationary phase; lipophagy ... See more keywords
Ginsenoside Compound K Protects against Obesity through Pharmacological Targeting of Glucocorticoid Receptor to Activate Lipophagy and Lipid Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061192
Abstract: (1) Background: The glucocorticoid receptor (GR) plays a key role in lipid metabolism, but investigations of GR activation as a potential therapeutic approach have been hampered by a lack of selective agonists. Ginsenoside compound K… read more here.
Keywords: lipophagy; ginsenoside compound; lipid metabolism; glucocorticoid receptor ... See more keywords