Novel hybrid block copolymer nanocarrier systems to load lipophilic drugs prepared by microphase inversion method
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DOI: 10.1007/s10965-017-1351-z
Abstract: Nanoparticles based on block copolymers of oligosaccharides [β-cyclodextrin (βCyD) and maltoheptaose (Mal7)] and poly(ε-caprolactone) (PCL) were prepared by microphase inversion method. Zeta-potential, particle size measurements and morphological analysis of drug-free and drug-loaded nanoparticles were performed… read more here.
Keywords: inversion method; block; microscopy; prepared microphase ... See more keywords
Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine
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DOI: 10.1007/s11095-019-2701-9
Abstract: Mucins are the principal glycoproteins in mucus and have been implicated in the limitation of intestinal drug absorption; however, the contribution of these molecules to intestinal drug absorption remains unclear. In this study, the relationship… read more here.
Keywords: intestine; intestinal permeation; lipophilic drugs; rat small ... See more keywords
Striking the Optimal Solubility-Permeability Balance in Oral Formulation Development for Lipophilic Drugs: Maximizing Carbamazepine Blood Levels.
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DOI: 10.1021/acs.molpharmaceut.6b00967
Abstract: The purpose of this research was to investigate the performance of cosolvent based solubility-enabling formulations in oral delivery of lipophilic drugs, accounting for the gastrointestinal tract (GIT) luminal solubilization processes, the solubility-permeability interplay, and the… read more here.
Keywords: lipophilic drugs; formulation; peg 400; solubility permeability ... See more keywords
Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface Modifications
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DOI: 10.3390/pharmaceutics15030772
Abstract: Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic and are used for treating diseases through various delivery routes, including skin absorption,… read more here.
Keywords: lipophilic drugs; surface modifications; drug delivery; drug ... See more keywords