Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700539
Abstract: A new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal… read more here.
Keywords: pyrrolidine dione; dione; lipophilicity; dione derivatives ... See more keywords
Structural insights into anticancer activity of D-ring modified estrone derivatives using their lipophilicity in estimation of SAR and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2242
Abstract: Many forms of breast carcinoma are hormone-dependent and therefore development of novel aromatase inhibitors is of particular interest. Since brain metastases are frequent in patients with advanced breast carcinoma, one of the goals of modern… read more here.
Keywords: docking studies; analysis; lipophilicity; structural insights ... See more keywords
Lipophilicity profiling of anthracycline antibiotics by microemulsion electrokinetic chromatography–effects on cardiotoxicity and endotheliotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900259
Abstract: Accurate profiling of the lipophilicity of amphoteric compounds might be complex and laborious. In the present work the lipophilicity of 12 anthracycline antibiotics–four parent drugs: doxorubicin, daunorubicin, epidoxorubicin, and epidaunorubicin and eight novel formamidyne derivatives… read more here.
Keywords: anthracycline antibiotics; lipophilicity profiling; lipophilicity; profiling anthracycline ... See more keywords
Hydration patterns of rings in drugs and relationship to lipophilicity: A DFT study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26808
Abstract: Rings are one of the major scaffold components of drugs in medicinal chemistry, due to their unique electronic distribution, scaffold rigidity, and three‐dimensionality while lipophilicity is considered as a vital parameter of rings that can… read more here.
Keywords: topology; hydration; chemistry; lipophilicity ... See more keywords
Lipophilicity assessment of some isoniazid derivatives active against Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.124820
Abstract: Abstract Micelle-water partition coefficients, log Kp(NaDS/w), and octanol-water partition coefficients, log Po/w, for 9 isoniazid derivatives, previously assessed as active against Mycobacterium tuberculosis, were determined using derivative spectrophotometry and the shake flask method in buffer… read more here.
Keywords: lipophilicity; mycobacterium tuberculosis; active mycobacterium; isoniazid derivatives ... See more keywords
On the characterization of novel biologically active steroids: Selection of lipophilicity models of newly synthesized steroidal derivatives by classical and non-parametric ranking approaches
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2019.03.001
Abstract: In this paper, the guidelines for the interpretation of the results of quantitative structure-retention relationship (QSRR) modeling, comparison and assessment of the established models, as well as the selection of the best and most consistent… read more here.
Keywords: characterization novel; lipophilicity; selection; model ... See more keywords
Insight into lipophilicity of deoxyribonucleoside‐boron cluster conjugates
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.09.036
Abstract: ABSTRACT Lipophilicity was investigated for 20 2′‐deoxyribonucleoside derivatives modified with electron‐neutral 1,2‐dicarba‐closo‐dodecaborane, 1,12‐dicarba‐closo‐dodecaborane, 7,8‐dicarba‐nido‐undecaborate anion, and metallacarborane containing Co, Fe, or Cr. The partition coefficient (P) for neutral conjugates and the distribution coefficient (D7.4) for… read more here.
Keywords: dicarba; closo dodecaborane; lipophilicity; lipophilicity deoxyribonucleoside ... See more keywords
Effects of intramolecular hydrogen bonds on lipophilicity
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.01.020
Abstract: ABSTRACT Intramolecular hydrogen bonds (IMHBs) affect the lipophilicity and physicochemical properties of small organic molecules and drug candidates. Considering IMHBs in drug design is an important strategy for improving the lipophilicity and physicochemical properties of… read more here.
Keywords: lipophilicity; water; intramolecular hydrogen; drug ... See more keywords
Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.03.036
Abstract: Abstract A series of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes as well as an ethylamine analog were synthesized. The compounds are either symmetrical with both axial ligands consisting of monoesters of succinic acid, or unsymmetrical, with one axial… read more here.
Keywords: lipophilicity; bis carboxylato; spectroscopy; oxalatobis propylamine ... See more keywords
Effect of charge of quaternary ammonium cations on lipophilicity and electroanalytical parameters: Task for ion transfer voltammetry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2017.04.051
Abstract: The electrochemical behavior of three differently charged drug molecules (zwitter-ionic acetylcarnitine, bi-cationic succinylcholine and tri-cationic gallamine) was studied at the interface between two immiscible electrolyte solutions. Tetramethylammonium was used as a model mono cationic molecule… read more here.
Keywords: lipophilicity; charge; effect charge; charge quaternary ... See more keywords
Lipophilicity of acetylcholine and related ions examined by ion transfer voltammetry at a polarized room-temperature ionic liquid membrane
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2018.03.019
Abstract: Abstract Ion transfer voltammetry at a polarized room-temperature ionic liquid (IL) membrane was used to evaluate the standard Gibbs energy of ion transfer from water to IL. This quantity was considered to be a measure… read more here.
Keywords: lipophilicity; ion; liquid membrane; ion transfer ... See more keywords