The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13559
Abstract: The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes… read more here.
Keywords: breast cancer; breast; lipoprotein lipase; microenvironment ... See more keywords
Orlistat response to missense mutations in lipoprotein lipase
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1500
Abstract: The human lipoprotein lipase (LPL) is a therapeutic target for obesity, and inhibition of LPL with the approved small molecule agent orlistat has been widely used in clinic to treat obesity‐related health problems such as… read more here.
Keywords: lipoprotein lipase; missense mutations; orlistat response; response missense ... See more keywords
Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.008
Abstract: Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl… read more here.
Keywords: maintains microglial; hchf diet; microglial innate; lipase maintains ... See more keywords
Gender-related relation between metabolic syndrome and S447X and HindIII polymorphisms of lipoprotein lipase gene in northern Iran.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.04.069
Abstract: BACKGROUND Metabolic syndrome is a cluster of conditions that increase risk of cardiovascular morbidity and mortality. Among genetic factors that contributed to incidence of metabolic syndrome, Polymorphisms of Lipoprotein lipase (LPL) are major candidates especially… read more here.
Keywords: gender related; polymorphisms lipoprotein; relation; metabolic syndrome ... See more keywords
Characterization of the new genetic variant in the caprine lipoprotein lipase gene
Sign Up to like & getrecommendations! Published in 2020 at "Small Ruminant Research"
DOI: 10.1016/j.smallrumres.2019.10.012
Abstract: Abstract Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyses the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins. By sequencing, we identified… read more here.
Keywords: new genetic; variant caprine; lipase; genetic variant ... See more keywords
Lipoprotein Lipase Sorting: Sphingomyelin and a Proteoglycan Show the Way.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.01.001
Abstract: A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al.… read more here.
Keywords: lipase sorting; sphingomyelin proteoglycan; sorting sphingomyelin; proteoglycan show ... See more keywords
Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00945
Abstract: Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPLS447X, causes a gain of function. This mutation truncates two… read more here.
Keywords: lipoprotein lipase; lpls447x; lipoprotein uptake; lpl ... See more keywords
Lipoprotein lipase is active as a monomer
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1900983116
Abstract: Significance Lipoprotein lipase (LPL) plays a central role in plasma lipid metabolism, hydrolyzing the triglycerides in lipoproteins and releasing fatty acid nutrients for vital tissues. LPL is synthesized by adipocytes and myocytes and secreted into… read more here.
Keywords: size; lipoprotein lipase; salt peak; lpl ... See more keywords
QnAs with Stephen G. Young
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215020119
Abstract: For more than half a century, a mystery shrouded the enzyme that breaks down triglycerides in the bloodstream: How does the enzyme, lipoprotein lipase, get from the interstitial spaces to its site of action inside… read more here.
Keywords: stephen young; lipoprotein lipase; qnas stephen;
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad261
Abstract: AIMS Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and is therefore a possible target for treating hypertriglyceridemia. Its relationship with cardiovascular risk has not been investigated in large-scale epidemiologic studies, particularly allowing… read more here.
Keywords: lipoprotein lipase; cardiovascular mortality; activity; apoc ... See more keywords
The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS)
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010483
Abstract: Background: Lipoprotein lipase (LPL) polymorphisms were suggested to be the risk factor for ischemic stroke (IS). However, controversial results were obtained. Our objective was to investigate the association of LPL polymorphisms at Ser447Ter, HindIII (+/−),… read more here.
Keywords: risk; lipoprotein lipase; model; hindiii pvuii ... See more keywords