Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23869
Abstract: The Alzheimer disease‐associated multifunctional low‐density lipoprotein receptor‐related protein‐1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock‐out… read more here.
Keywords: radial glia; density; receptor; lipoprotein receptor ... See more keywords
MicroRNA‐590‐3p inhibits trophoblast‐dependent maternal spiral artery remodeling by repressing low‐density lipoprotein receptor‐related protein 6
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.491
Abstract: The remodeling of maternal spiral artery following embryo implantation, which relies on well‐regulated trophoblast functions, is a pivotal process to ensure a successful pregnancy. Low‐density lipoprotein receptor‐related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are… read more here.
Keywords: spiral artery; density lipoprotein; low density; lipoprotein receptor ... See more keywords
High Bone Mass From Mutation Of Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6).
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115550
Abstract: Wnt/β-catenin signaling is important for skeletal development and health. Eleven heterozygous gain-of-function missense mutations within the first β-propeller of low-density lipoprotein receptor-related protein 5 (LRP5) are known to cause the autosomal dominant disorder called high… read more here.
Keywords: receptor related; density lipoprotein; bone; low density ... See more keywords
Low-density lipoprotein receptor-related protein-1 (LRP1) targeting contrast-enhanced MRI as a novel strategy for epilepsy imaging
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103212
Abstract: a Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States b Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China c Center of Epilepsy, Beijing… read more here.
Keywords: epilepsy; receptor related; density lipoprotein; low density ... See more keywords
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154191
Abstract: BACKGROUND Low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in fatty acid metabolism and glucose homeostasis. In the context of dyslipemia, LRP1 is upregulated in the heart. Our aim was to evaluate the… read more here.
Keywords: lipoprotein receptor; density lipoprotein; lrp1; low density ... See more keywords
Double-seropositive myasthenia gravis with acetylcholine receptor and low-density lipoprotein receptor-related protein 4 antibodies associated with invasive thymoma
Sign Up to like & getrecommendations! Published in 2017 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2017.06.001
Abstract: We describe two cases of myasthenia gravis (MG) with double seropositivity for acetylcholine receptor (AChR) and low-density lipoprotein receptor-related protein 4 (LRP4) antibodies (AChR/LRP4-MG) with invasive thymoma. Both cases showed myasthenic weakness, which was restricted… read more here.
Keywords: lipoprotein receptor; density lipoprotein; low density; myasthenia gravis ... See more keywords
Dietary corn fractions reduce atherogenesis in low-density lipoprotein receptor knockout mice.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition research"
DOI: 10.1016/j.nutres.2016.12.005
Abstract: Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate… read more here.
Keywords: corn; density lipoprotein; low density; mice ... See more keywords
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92711-0
Abstract: Apolipoprotein A4 (APOA4) is one of the most abundant and versatile apolipoproteins facilitating lipid transport and metabolism. APOA4 is synthesized in the small intestine, packaged onto chylomicrons, secreted into intestinal lymph and transported via circulation… read more here.
Keywords: protein; apolipoprotein apoa4; lrp1; tissue ... See more keywords
Lipoprotein Receptor Signaling in Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz338
Abstract: The founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis of LDL particles and regulation of cholesterol homeostasis. Since the discovery of… read more here.
Keywords: density lipoprotein; low density; lipoprotein; receptor ... See more keywords
Functional characterization of a low-density lipoprotein receptor in the lepidopteran model, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13018
Abstract: The growth and development of metabolous insects are mainly regulated by ecdysone and juvenile hormone. As a member of the low-density lipoprotein receptor (LDLR) family, megalin (mgl) is involved in the lipoprotein transport of cholesterol… read more here.
Keywords: insects; development; density lipoprotein; low density ... See more keywords
Association of type 2 diabetes mellitus with the interaction between low‐density lipoprotein receptor‐related protein 5 (LRP5) polymorphisms and overweight and obesity in rural Chinese adults
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12522
Abstract: Low‐density lipoprotein receptor‐related protein 5 (LRP5) plays an important role in glucose and cholesterol metabolism. The present cohort study evaluated associations of LRP5 variants with the incidence of type 2 diabetes mellitus (T2DM) in a… read more here.
Keywords: receptor related; density lipoprotein; low density; related protein ... See more keywords