Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma
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DOI: 10.18632/oncotarget.13485
Abstract: Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor… read more here.
Keywords: liposarcoma; exportin; liposarcoma cells; molecular mechanism ... See more keywords
Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells
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DOI: 10.18632/oncotarget.22743
Abstract: Liposarcoma is a common subtype of soft tissue sarcoma and accounts for 20% of all sarcomas. Conventional chemotherapeutic agents have limited efficacy in liposarcoma patients. Expression and activation of serine/threonine-protein kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase… read more here.
Keywords: liposarcoma; cells targeting; dyrk1b suppresses; liposarcoma cells ... See more keywords