Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin
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DOI: 10.1016/j.jconrel.2019.01.004
Abstract: ABSTRACT Acidic pH in the tumor microenvironment is associated with cancer metabolism and creates a physiological barrier that prevents from drugs to penetrate cells. Specifically, ionizable weakâbase drugs, such as doxorubicin, freely permeate membranes in… read more here.
Keywords: liposomal bicarbonate; doxorubicin; bicarbonate; sodium bicarbonate ... See more keywords